{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:36:42Z","timestamp":1789673802290,"version":"4.0.1"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> Neuropilin 1 (NRP-1) is a novel co-receptor promoting SARS-CoV-2 infectivity. Animal data indicate a role in trans-endothelial lipid transport and storage. As human data are sparse, we aimed to assess the role of NRP-1 in 2 metabolic active tissues in human obesity and in the context of weight loss-induced short- and long-term metabolic changes. <b><i>Methods:<\/i><\/b> After a standardized 12-week weight reduction program, 143 subjects (age &#x3e;18; body mass index \u226527 kg\/m<sup>2<\/sup>, 78% female) were randomized to a 12-month lifestyle intervention or a control group using a stratified randomization scheme. This was followed by 6-month follow-up without any intervention. Phenotyping was performed before and after weight loss, after 12-month intervention and after subsequent 6 months of follow-up. Tissue-specific insulin sensitivity was estimated by HOMA-IR (whole body and mostly driven by liver), insulin sensitivity index (ISI)<sub>Clamp<\/sub> (predominantly skeletal muscle), and free fatty acid (FFA) suppression during hyperinsulinemic-euglycemic clamp (FFA<sub>Supp<\/sub>) (predominantly adipose tissue). NRP-1 mRNA expression was measured in subcutaneous adipose tissue (NRP-1<sub>AT<\/sub>) and skeletal muscle (NRP-1<sub>SM<\/sub>) before and after weight loss. <b><i>Results:<\/i><\/b> NRP-1 was highly expressed in adipose tissue (7,893 [7,303\u20138,536] counts), but neither NRP-1<sub>AT<\/sub> nor NRP-1<sub>SM<\/sub> were related to estimates of obesity. Higher NRP-1<sub>AT<\/sub> was associated with stronger FFA<sub>Supp<\/sub> (<i>r<\/i> = \u22120.343, <i>p<\/i> = 0.003) and a tendency to higher ISI<sub>Clamp<\/sub> (<i>r<\/i> = 0.202, <i>p<\/i> = 0.085). Weight loss induced a decline of NRP-1<sub>AT<\/sub> but not NRP-1<sub>SM<\/sub>. This was more pronounced in subjects with stronger reduction of adipose ACE-2 mRNA expression (<i>r<\/i> = 0.250; <i>p<\/i> = 0.032) but was not associated with short- and long-term improvement of FFA<sub>Supp<\/sub> and ISI<sub>Clamp<\/sub>. <b><i>Conclusion:<\/i><\/b> NRP-1<sub>AT<\/sub> is related to adipose insulin sensitivity in obesity. Weight loss-induced decline of NRP-1<sub>AT<\/sub> seems not to be involved in metabolic short- and long-term improvements after weight loss. However, weight loss-induced reduction of both NRP-1<sub>AT<\/sub> and ACE-2<sub>AT<\/sub> indicates a lower susceptibility of adipose tissue for SARS-CoV-2 after body weight reduction.<\/jats:p>","DOI":"10.1159\/000520419","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T17:00:39Z","timestamp":1639155639000},"page":"90-98","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Weight Loss on Adipose and Muscular Neuropilin 1 mRNA Expression in Obesity: Potential Implication in SARS-CoV-2 Infections?"],"prefix":"10.1159","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7377-0220","authenticated-orcid":false,"given":"Dominik","family":"Soll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finja","family":"Beer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4316-2961","authenticated-orcid":false,"given":"Leonard","family":"Spranger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-9243","authenticated-orcid":false,"given":"Linna","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Spranger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0126-3155","authenticated-orcid":false,"given":"Knut","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.04.021"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1996"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3325"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177\/1479972308096978"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81402-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2147\/BTT.S307352"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1035"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-01162-z"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22843"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0551"}],"container-title":["Obesity Facts"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:29:20Z","timestamp":1745407760000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000520419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,10]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,17]]},"published-print":{"date-parts":[[2022,1,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000520419","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.17158040","asserted-by":"subject"}]},"ISSN":["1662-4025","1662-4033"],"issn-type":[{"value":"1662-4025","type":"print"},{"value":"1662-4033","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,10]]}}}