{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:36:35Z","timestamp":1784932595935,"version":"3.55.0"},"reference-count":39,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> We experienced an increased incidence of meconium-related ileus (MRI) in extremely premature infants (EPIs) while adopting the antenatal magnesium sulfate (MgSO<sub>4<\/sub>) protocol for fetal neuroprotection in our neonatal intensive care unit. This study aimed to test whether antenatal MgSO<sub>4<\/sub> use was associated with increased risk of MRI in EPIs. <b><i>Methods:<\/i><\/b> The incidences of complicated MRI requiring aggressive enema or surgical intervention and other intestinal complications were compared among period 1 (January 2012\u2013December 2013, <i>n<\/i> = 79), before adoption of the antenatal MgSO<sub>4<\/sub> protocol for fetal neuroprotection; period 2 (January 2014\u2013March 2016, <i>n<\/i> = 72), when the protocol was adopted; and period 3 (April 2016\u2013September 2018, <i>n<\/i> = 75), when the protocol was temporarily withdrawn due to concern regarding intestinal complications in EPIs. <b><i>Results:<\/i><\/b> Despite similar baseline clinical characteristics among infants across the study periods, the MRI and MRI with surgical treatment incidences were higher in period 2 than those in periods 1 and 3 (13% vs. 8% and 6%, <i>p<\/i> = 0.391, and 11% vs. 0% and 1%, <i>p<\/i> = 0.001, respectively). In multivariable analysis, exposure to antenatal MgSO<sub>4<\/sub> independently increased the risk of MRI (adjusted odds ratio, 3.8; 95% confidence interval, 1.4, 10.6). <b><i>Conclusion:<\/i><\/b> Antenatal MgSO<sub>4<\/sub> may increase the risk of MRI, frequently requiring surgical intervention, in EPIs with a gestational age of 25 weeks or less. <\/jats:p>","DOI":"10.1159\/000520452","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T22:00:48Z","timestamp":1641938448000},"page":"68-76","source":"Crossref","is-referenced-by-count":16,"title":["Increased Risk of Meconium-Related Ileus in Extremely Premature Infants Exposed to Antenatal Magnesium Sulfate"],"prefix":"10.1159","volume":"119","author":[{"given":"Se In","family":"Sung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yoon","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-4789","authenticated-orcid":false,"given":"Suk-Joo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-0048","authenticated-orcid":false,"given":"Soo-young","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheong-Rae","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9201-2938","authenticated-orcid":false,"given":"Yun Sil","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Soon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000236445.18265.93"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001060.pub2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05313-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01166.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801187"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.04.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a60495"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004661.pub3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.106"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1581059"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2015.89.3.151"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12815"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60016-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3468(96)90153-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.285"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1148\/125.2.457"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-7070-y"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(03)00123-4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/nu9101125"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69785-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.274"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1603344"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(76)90281-5"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197204132861507"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(64)90608-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/s1055-8586(00)70020-5"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.190157"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159\/000319049"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1424823"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1998.10718775"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.138024"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159\/000100804"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.307"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2019.34.e271"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.01.027"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-011-2906-4"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05417-0"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002988"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-017-0702-9"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:29:38Z","timestamp":1745422178000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000520452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,2,16]]},"published-print":{"date-parts":[[2022,3,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000520452","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}