{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:57:22Z","timestamp":1789343842885,"version":"build-2803163510"},"reference-count":55,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Previous studies identified myopia as a risk factor for primary open-angle glaucoma (POAG). However, recent studies have shown different results, and the definitive relationship between myopia and POAG remains controversial. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to investigate the relationship between myopia and POAG. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Published articles were searched from PubMed, Embase, and Scopus databases between 1970 and 2020. A pooled analysis of the odds ratios (ORs) was performed using a random-effects model. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Data on the association between myopia and POAG were obtained from 16 cross-sectional studies, and the pooled OR was 2.26 (95% confidence interval [CI], 1.77\u20132.89, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) in random-effects model (&lt;i&gt;I&lt;\/i&gt;&lt;sup&gt;2&lt;\/sup&gt; = 86%; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01). For the relationship of myopia and POAG progression, data from 7 longitudinal cohort studies were included, and the pooled OR was 0.85 (95% CI, 0.73\u20130.99&lt;i&gt;, p&lt;\/i&gt; = 0.042) in the random-effects model (&lt;i&gt;I&lt;\/i&gt;&lt;sup&gt;2&lt;\/sup&gt; = 88%; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Our findings demonstrated that myopia may be a risk factor associated with POAG and a possible protective factor for POAG progression. It may be due to myopia with the presence of a lamina cribrosa defect, slowing down the visual field loss and also POAG progression. Further research for underlying mechanisms is still needed. <\/jats:p>","DOI":"10.1159\/000520468","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T22:00:39Z","timestamp":1639087239000},"page":"387-397","source":"Crossref","is-referenced-by-count":30,"title":["The Association between Myopia and Primary Open-Angle Glaucoma: A Systematic Review and 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