{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:41:09Z","timestamp":1778838069293,"version":"3.51.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The rapid worldwide increase in the incidence of Alzheimer\u2019s disease is associated with changing nutrition patterns. Recently, some articles have highlighted the link between Alzheimer\u2019s disease and dietary cholesterol. It was found that elevated levels of some of its fractions in the brain and circulation affect metabolism. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; Previous studies have considered the relationship between Alzheimer\u2019s disease and oxidized cholesterol molecules in the brain. To date, there are limited data available on the relationship between oxidized cholesterol in the brain and Alzheimer\u2019s disease. There is a link between a diet high in cholesterol and its oxidized forms, leading to hypercholesterolemia, which is one of significant risk factors of dementia, and Alzheimer\u2019s disease. Oxidized cholesterol can be absorbed in the small intestine and cross the blood-brain barrier, leading to increased inflammation and endogenous oxidative process. Animal-origin foods are sources of oxidized cholesterol, with cholesterol oxidation beginning already after slaughter and occurring during storage and processing. &lt;b&gt;&lt;i&gt;Key Messages:&lt;\/i&gt;&lt;\/b&gt; High-heat food preparation and storage of cooked products in the refrigerator followed by subsequent heating may significantly increase the amount of oxidized cholesterol products. Therefore, a diet low in cholesterol oxidation products and high in plants with antioxidative properties seems to be most preventable and should be implemented as early as possible. <\/jats:p>","DOI":"10.1159\/000520514","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T21:00:36Z","timestamp":1652302836000},"page":"125-132","source":"Crossref","is-referenced-by-count":9,"title":["Metabolism and the Effect of Animal-Derived Oxysterols in the Diet on the Development of Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"78","author":[{"given":"Miko\u0142aj","family":"Choroszy\u0144ski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Barcikowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Barczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.03.009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2009.035"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700689"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.13423"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00119"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2012.12.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-019-1221-y"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0153-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00731-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2017.1416942"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1674808"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.07.015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00278"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1541"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191023"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11934"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00556"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2020.105785"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9874159"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00755-y"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00150"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.09.013"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.10.034"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.05.059"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2012.11.005"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.02.010"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:30:06Z","timestamp":1745422206000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000520514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,6,9]]},"published-print":{"date-parts":[[2022,6,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000520514","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}