{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:00:36Z","timestamp":1772164836648,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord Extra"],"abstract":"<jats:p>Background: Individuals with Down syndrome (DS) are at high risk of dementia which is difficult to diagnose in DS. Neuroimaging has been identified as a potential tool to aid diagnosis by detecting changes in brain function. We carried out a review comparing functional neuroimaging in DS individuals with and without dementia. Summary: A literature search was conducted using PubMed to identify relevant studies. In DS subjects with dementia, fluorodeoxyglucose-positron emission tomography (PET) studies showed glucose hypometabolism particularly in the parietal and\/or temporal regions whilst magnetic resonance spectroscopy studies showed increased myoinositol and decreased N-acetylaspartate. Ligand-based PET studies revealed significant Pittsburgh compound B binding in DS subjects over the age of 40, particularly if they had dementia. Key Messages: Neuroimaging may aid the early detection of dementia in DS; however, further longitudinal studies are required.<\/jats:p>","DOI":"10.1159\/000520880","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T17:01:03Z","timestamp":1640624463000},"page":"324-332","source":"Crossref","is-referenced-by-count":1,"title":["A Review of Functional Neuroimaging in People with Down Syndrome with and without Dementia"],"prefix":"10.1159","volume":"11","author":[{"given":"Funmi","family":"Deinde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-8658","authenticated-orcid":false,"given":"Jay","family":"Kotecha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian Suh Lih","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagnik","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7712-930X","authenticated-orcid":false,"given":"Latha","family":"Velayudhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,12,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00063-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2217\/nmt.15.8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-006-9047-x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(92)90096-g"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.10.022"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2174\/1567205012666150921095724"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00191"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.09.064"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(86)90010-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.38.6.938"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000106700"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.5.738"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2007-11110"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.12.1360"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199605310-00014"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940040203"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2217\/fnl.14.13"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.2.197"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330619"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394816-8.00002-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2004.00616.x"}],"updated-by":[{"DOI":"10.1159\/000523742","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000}}],"container-title":["Dementia and Geriatric Cognitive Disorders Extra"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dee\/article-pdf\/11\/3\/324\/4021409\/000520880.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dee\/article-pdf\/11\/3\/324\/4021409\/000520880.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:33:57Z","timestamp":1745408037000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000520880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,27]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,1,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000520880","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.1159\/000523742","asserted-by":"object"}]},"ISSN":["1664-5464"],"issn-type":[{"value":"1664-5464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,27]]}}}