{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:56:28Z","timestamp":1790790988515,"version":"4.1.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Animal-assisted intervention has become a common therapeutic practice used for patients with dementia in home-dwelling and institutions. The most established procedure is a visiting service by specially trained dogs and their owners to improve social interactions and reduce symptoms of agitation. <b><i>Objectives:<\/i><\/b> The study aims to investigate the effects of a therapy dog on agitation of inpatients with dementia in a gerontopsychiatric ward. <b><i>Materials and Methods:<\/i><\/b> The severity of agitation was assessed by a rater blinded for the presence of the dog via the Overt Agitation Severity Scale (OASS). The scale was conducted on 1 day with the dog and his handler present (resident doctor on the ward) and on another day with only the handler present. Each patient was his\/her own control. Heart rate variability (HRV) and serum level of brain-derived neurotrophic factor (BDNF) of the patients were measured on both days. 26 patients with the Mini-Mental Status Examination (MMSE) score &#x3c;21 and the diagnosis of dementia were included in the study. <b><i>Results:<\/i><\/b> A significant reduction of agitation in the OASS could be shown when the dog was present (<i>p<\/i> = 0.006). The data neither demonstrated a difference in the HRV for the parameters mean heart rate (<i>p<\/i> = 0.65), root mean square of successive differences (<i>p<\/i> = 0.63), and high frequencies (<i>p<\/i> = 0.27) nor in serum BDNF concentrations (<i>p<\/i> = 0.42). <b><i>Discussion:<\/i><\/b> Therapy dogs can be implemented as a therapeutic tool in a gerontopsychiatric ward to reduce symptoms of agitation in patients with dementia. The study was registered in the German Clinical Trials Register (DRKS00024093). <\/jats:p>","DOI":"10.1159\/000520881","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T22:00:35Z","timestamp":1640815235000},"page":"541-547","source":"Crossref","is-referenced-by-count":2,"title":["Treating Agitation in Patients with Dementia with a Therapy Dog in a Milieu Therapy Setting on a Geropsychiatric Ward"],"prefix":"10.1159","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-9559","authenticated-orcid":false,"given":"Jana","family":"Kr\u00fcger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyhan","family":"Izgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Hellweg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Str\u00f6hle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Jockers-Scher\u00fcbl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.12.1475"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13604"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-019-0572-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.03.015"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3928\/0279-3695-19990401-12"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.00213"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.02.013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.9.4.541"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-4886(03)00127-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/153331750301800610"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/019394502320555421"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000484890"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.96.4.1209"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-003-0100-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03135.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076050"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:33:58Z","timestamp":1745422438000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000520881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":16,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3,3]]},"published-print":{"date-parts":[[2022,3,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000520881","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}