{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:50:45Z","timestamp":1778028645939,"version":"3.51.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> Bronchoscopic lung volume reduction (BLVR) using 1-way endobronchial valves (EBV) has become a guideline treatment in patients with advanced emphysema. Evidence from this minimally invasive treatment derives mainly from well-designed controlled trials conducted in high-volume specialized intervention centres. Little is known about real-life outcome data in hospitals setting up this novel treatment and which favourable conditions are required for a continuous successful program. <b><i>Objectives:<\/i><\/b> In this study, we aim to evaluate the eligibility rate for BLVR and whether the implementation of BLVR in our academic hospital is feasible and yields clinically significant outcomes. <b><i>Method:<\/i><\/b> A retrospective evaluation of patients treated with EBV between January 2016 and August 2019 was conducted. COPD assessment test (CAT), forced expiratory volume in 1 s (FEV<sub>1<\/sub>), residual volume (RV), and 6-min walking test (6MWT) were measured at baseline and 3 months after intervention. Paired sample <i>t<\/i> tests were performed to compare means before and after intervention. <b><i>Results:<\/i><\/b> Of 350 subjects screened, 283 (81%) were not suitable for intervention mostly due to lack of a target lobe. The remaining 67 subjects (19%) underwent bronchoscopic assessment, and if suitable, valves were placed in the same session. In total, 55 subjects (16%) were treated with EBV of which 10 did not have complete follow-up: 6 subjects had their valves removed because of severe pneumothorax (<i>n<\/i> = 2) or lack of benefit (<i>n<\/i> = 4) and the remaining 4 had missing follow-up data. Finally, 45 patients had complete follow-up at 3 months and showed an average change \u00b1 SD in CAT \u22124 \u00b1 6 points, FEV<sub>1<\/sub> +190 \u00b1 140 mL, RV \u2212770 \u00b1 790 mL, and +37 \u00b1 65 m on the 6MWT (all <i>p<\/i> &#x3c; 0.001). After 1-year follow-up, 34 (76%) subjects had their EBV in situ. <b><i>Conclusion:<\/i><\/b> Implementing BLVR with EBV is feasible and effective. Only 16% of screened patients were eligible, indicating that this intervention is only applicable in a small subset of highly selected subjects with advanced emphysema, and therefore a high volume of COPD patients is essential for a sustainable BLVR program. <\/jats:p>","DOI":"10.1159\/000520885","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T22:00:29Z","timestamp":1640210429000},"page":"476-484","source":"Crossref","is-referenced-by-count":5,"title":["Implementation of Bronchoscopic Lung Volume Reduction Using One-Way Endobronchial Valves: A Retrospective Single-Centre Cohort Study"],"prefix":"10.1159","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0015-0116","authenticated-orcid":false,"given":"Rein","family":"Posthuma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouk W.","family":"Vaes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim H. M.","family":"Walraven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyman","family":"Sardari Nia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-4840","authenticated-orcid":false,"given":"Jan U.","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hester A.","family":"Gietema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geertjan","family":"Wesseling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiel F. M.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-4096","authenticated-orcid":false,"given":"Lowie E. G. W.","family":"Vanfleteren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.02.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507807"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000453529"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000453588"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633722"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1081\/copd-200053377"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.10.017"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00219111"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-019-00303-7"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:34:01Z","timestamp":1745422441000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000520885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,2]]},"published-print":{"date-parts":[[2022,5,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000520885","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,22]]}}}