{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T09:34:07Z","timestamp":1771148047082,"version":"3.50.1"},"reference-count":4,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflamm Intest Dis"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> Given the lack of data, we aimed to assess the impact of the length of diagnostic delay on the natural history of ulcerative colitis (UC) in pediatric (diagnosed &#x3c;18 years) and adult patients (diagnosed \u226518 years). <b><i>Methods:<\/i><\/b> Data from the Swiss Inflammatory Bowel Disease Cohort Study were analyzed. Diagnostic delay was defined as the interval between the first appearance of UC-related symptoms until diagnosis. Logistic regression modeling evaluated the appearance of the following complications in the long term according to the length of diagnostic delay: colonic dysplasia, colorectal cancer, UC-related hospitalization, colectomy, and extraintestinal manifestations (EIMs). <b><i>Results:<\/i><\/b> A total of 184 pediatric and 846 adult patients were included. The median diagnostic delay was 4 [IQR 2\u20137.5] months for the pediatric-onset group and 3 [IQR 2\u201310] months for the adult-onset group (<i>p<\/i> = 0.873). In both, pediatric- and adult-onset groups, the length of diagnostic delay at UC diagnosis was not associated with colectomy, UC-related hospitalization, colon dysplasia, and colorectal cancer. EIMs were significantly more prevalent at UC diagnosis in the adult-onset group with long diagnostic delay than in the adult-onset group with short diagnostic delay (<i>p<\/i> = 0.022). In the long term, the length of diagnostic delay was associated in the adult-onset group with colorectal dysplasia (<i>p<\/i> = 0.023), EIMs (<i>p<\/i> &#x3c; 0.001), and more specifically arthritis\/arthralgias (<i>p<\/i> &#x3c; 0.001) and ankylosing spondylitis\/sacroiliitis (<i>p<\/i> &#x3c; 0.001). In the pediatric-onset UC group, the length of diagnostic delay in the long term was associated with arthritis\/arthralgias (<i>p<\/i> = 0.017); however, it was not predictive for colectomy and UC-related hospitalization. <b><i>Conclusions:<\/i><\/b> As colorectal cancer and EIMs are associated with considerable morbidity and costs, every effort should be made to reduce diagnostic delay in UC patients. <\/jats:p>","DOI":"10.1159\/000520995","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T14:06:35Z","timestamp":1639058795000},"page":"87-96","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Diagnostic Delay on Disease Course in Pediatric- versus Adult-Onset Patients with Ulcerative Colitis: Data from the Swiss IBD Cohort"],"prefix":"10.1159","volume":"7","author":[{"given":"Alain M.","family":"Schoepfer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vu Dang Chau","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5803-3233","authenticated-orcid":false,"given":"Jean-Benoit","family":"Rossel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Sokollik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Spalinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1505-7750","authenticated-orcid":false,"given":"Ekaterina","family":"Safroneeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thea","family":"von Graffenried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Godat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Hahnloser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan R.","family":"Vavricka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Braegger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0063-3580","authenticated-orcid":false,"given":"Andreas","family":"Nydegger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Swiss IBD Cohort Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21349"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.016"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2017.10.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13478"}],"container-title":["Inflammatory Intestinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:35:24Z","timestamp":1745422524000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000520995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,18]]},"references-count":4,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,7,5]]},"published-print":{"date-parts":[[2022,7,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000520995","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.17040389","asserted-by":"subject"}]},"ISSN":["2296-9403","2296-9365"],"issn-type":[{"value":"2296-9403","type":"print"},{"value":"2296-9365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,18]]}}}