{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T03:39:09Z","timestamp":1776051549444,"version":"3.50.1"},"reference-count":107,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Dev"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Background: In eutherian mammals, the sex chromosome complement, XX and XY, determines sexual differentiation of gonadal primordia into testes and ovaries, which in turn direct differentiation of germ cells into haploid sperm and oocytes, respectively. When gonadal sex is reversed, however, the germ cell sex becomes discordant with the chromosomal sex. XY females in humans are infertile, while XY females in the mouse (Mus musculus) are subfertile or infertile dependent on the cause of sex reversal and the genetic background. This article reviews publications to understand how the sex chromosome complement affects the fertility of XY oocytes by comparing with XX and monosomy X (XO) oocytes. Summary: The results highlight 2 folds disadvantage of XY oocytes over XX oocytes: (1) the X and Y chromosomes fail to pair during the meiotic prophase I, resulting in sex chromosome aneuploidy at the first meiotic division and (2) expression of the Y-linked genes during oocyte growth affects the transcriptome landscape and renders the ooplasmic component incompetent for embryonic development. Key Message: The XX chromosome complement gives the oocyte the highest competence for embryonic development. <\/jats:p>","DOI":"10.1159\/000521151","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T16:28:11Z","timestamp":1646238491000},"page":"355-364","source":"Crossref","is-referenced-by-count":5,"title":["Role of the X and Y Chromosomes in the Female Germ Cell Line Development in the Mouse (Mus musculus)"],"prefix":"10.1159","volume":"16","author":[{"given":"Wataru","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seang Lin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruko","family":"Taketo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/164.1.277"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-07-0383"},{"key":"ref3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/351406a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.3.1041-1053.2005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(74)90106-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.045930"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-6-213"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005079"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00360403"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201500040"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701677104"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90195-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0610207"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000056819"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0680387"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/ng1193-301"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx398"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/nature03479"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1017\/s0016672300003335"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0040030"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-015-0568-z"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005462"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(01)00284-7"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.11.002"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35380"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/ng0394-245"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9947"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000860"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080360110"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.163"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1126\/science.7089579"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401900112"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1996.00057.x"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/s1534-5807(03)00093-5"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90416-c"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.2741\/2189"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007895"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.coemr.2020.11.010"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0125-4"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229277"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008676"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2006.00943.x"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-002-0195-3"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.13.2417"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-014-1420-x"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.11.2007"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1242\/dev.111.4.1137"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8972"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402200311"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1242\/dev.048983"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.9.1823"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1038\/31482"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.10.003"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a110923"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1242\/dev.107052"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.1020170306"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.8.1807"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/156.2.775"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.7.1611"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.07.038"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-82"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118403109"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.06.057"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.2017-033"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1038\/nature23318"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1119(01)00479-6"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1126\/science.2563174"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1987.tb01561.x"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802680105"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1007\/BF00209476"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.022"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.017541"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2011.04.007"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy214"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.12.023"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz1111"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1530\/JME-14-0018"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091550309"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1038\/ng.864"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.15.6938"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402150209"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.16.2535"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.09.008"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030116"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.11.2.521"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20352"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1242\/dev.107.1.95"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1242\/dev.118.1.171"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1038\/nature24265"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1210\/endo-23-5-566"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1038\/ng1484"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001710309"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaaa049"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1242\/dev.091165"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0769-z"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(93)90341-s"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.10.034"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8109-z"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz5004"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051560206"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.11.004"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040481"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.792604"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1101\/gr.103200.109"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00922-1"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080410410"}],"container-title":["Sexual Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/sxd\/article-pdf\/16\/5-6\/355\/3941439\/000521151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/sxd\/article-pdf\/16\/5-6\/355\/3941439\/000521151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:37:05Z","timestamp":1745422625000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000521151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":107,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2023,7,11]]},"published-print":{"date-parts":[[2023,7,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000521151","archive":["Portico"],"relation":{},"ISSN":["1661-5425","1661-5433"],"issn-type":[{"value":"1661-5425","type":"print"},{"value":"1661-5433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}