{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T05:03:43Z","timestamp":1749618223467,"version":"3.40.5"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> Few studies have reported a double-step follow-up of patients after hospitalization for COVID-19. <b><i>Objectives:<\/i><\/b> We designed an observational double-step follow-up study with a clinical, functional, and radiological evaluation at 2 and 6 months after COVID-19. The primary outcome was to describe symptoms, spirometry, and 6-minute walking test (6MWT) at 2 and 6 months. Secondary outcomes were to identify if the lowest PaO<sub>2<\/sub>\/FiO<sub>2<\/sub> during hospitalization is related with functional and radiological evolution and to assess the correlation between radiological and functional abnormalities at 6 months. <b><i>Methods:<\/i><\/b> Symptoms, spirometry, and 6MWT were assessed at 2 and 6 months; arterial blood gas, chest x-ray, and lung ultrasound were performed at 2 months; body plethysmography, diffusing capacity for carbon monoxide (DLCO), and CT scan were performed at 6 months. <b><i>Results:<\/i><\/b> Sixty-four per cent and 42% of patients reported at least one symptom at 2 and 6 months, respectively. The most common 6-month functional alteration was DLCO impairment (57% of patients). An improvement of FEV1, FVC, and 6MWT was observed between 2 and 6 months (<i>p<\/i> &#x3c; 0.001). Patients with PaO<sub>2<\/sub>\/FiO<sub>2<\/sub> &#x3c;200 during hospitalization performed worse at 6MWT at 2 and 6 months (<i>p<\/i> &#x3c; 0.05) and reported more extended radiological abnormalities at 6 months (<i>p<\/i> &#x3c; 0.001) compared with patients with PaO<sub>2<\/sub>\/FiO<sub>2<\/sub>&#x3e;200. At 6 months, more extended radiological abnormalities were related with worse 6MWT, DLCO, and total lung capacity (<i>p<\/i> &#x3c; 0.05). <b><i>Discussion:<\/i><\/b> DLCO and 6MWT impairment seem to be the functional hallmark of COVID-19 and are related with the severity of acute pneumonia. At 6 months, radiological abnormalities were related to functional impairment. <\/jats:p>","DOI":"10.1159\/000521316","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T22:00:50Z","timestamp":1642543250000},"page":"381-393","source":"Crossref","is-referenced-by-count":9,"title":["Spontaneous Evolution of COVID-19 Lung Sequelae: Results from a Double-Step Follow-Up"],"prefix":"10.1159","volume":"101","author":[{"given":"Martina","family":"Ferioli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2709-919X","authenticated-orcid":false,"given":"Irene","family":"Prediletto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Bensai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-4660","authenticated-orcid":false,"given":"Sara","family":"Betti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Daniele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Di Scioscio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Modolon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rita","family":"Rimondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"De Molo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-0745","authenticated-orcid":false,"given":"Carla","family":"Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Nava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Fasano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12603"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01832-2020"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000514387"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06879-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.04015-2020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000518141"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02992-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2020.101166"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-215314"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150314"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00008483-200103000-00005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-020-01200-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-020-01202-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000512782"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.08.080"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2021.106384"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:39:04Z","timestamp":1745422744000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000521316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,1]]},"published-print":{"date-parts":[[2022,4,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000521316","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2022]]}}}