{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:10:55Z","timestamp":1781277055290,"version":"3.54.1"},"reference-count":8,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> Radiation-associated sarcoma (RAS) is one of the most life-threatening complications associated with the treatment of malignant neoplasms. Because all RAS patients have a history of radiotherapy, there have been no effective treatment options when RAS is not completely resected. <b><i>Methods:<\/i><\/b> We retrospectively reviewed 20 RAS patients, including 4 unresectable cases treated by carbon ion radiotherapy (CIRT). <b><i>Results:<\/i><\/b> The primary diseases targeted by radiotherapy included malignant lymphoma (<i>n<\/i> = 4), cervical cancer (<i>n<\/i> = 3), pharyngeal cancer (<i>n<\/i> = 3), breast cancer (<i>n<\/i> = 2), lung cancer (<i>n<\/i> = 1), rectal cancer (<i>n<\/i> = 1), maxillary cancer (<i>n<\/i> = 1), synovial sarcoma (<i>n<\/i> = 1), and benign neoplasms (<i>n<\/i> = 4). The histological diagnoses of RAS included osteosarcoma (<i>n<\/i> = 8), leiomyosarcoma (<i>n<\/i> = 3), undifferentiated pleomorphic sarcoma (<i>n<\/i> = 3), rhabdomyosarcoma (<i>n<\/i> = 1), angiosarcoma (<i>n<\/i> = 1), malignant peripheral nerve sheath tumor (<i>n<\/i> = 1), spindle cell sarcoma NOS (<i>n<\/i> = 1), and sarcoma not further specified (<i>n<\/i> = 2). The median survival time from the diagnosis of RAS was 26 months. Eleven patients underwent surgery. Five of these patients achieved a continuous disease free (CDF) status or showed no evidence disease. Four patients underwent CIRT. One of these patients with leiomyosarcoma achieved a CDF status, and the other patient with osteosarcoma achieved a partial response. On the other hand, 2 patients experienced grade 3 toxicities that required surgical treatment. <b><i>Conclusion:<\/i><\/b> RAS originates from various types of diseases that are treated by radiotherapy and shows diverse pathological features. Complete resection achieves a good prognosis. CIRT can be an effective and feasible option for unresectable RAS. <\/jats:p>","DOI":"10.1159\/000521504","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T22:00:31Z","timestamp":1639692031000},"page":"148-154","source":"Crossref","is-referenced-by-count":2,"title":["An Analysis of 20 Cases of Radiation-Associated Sarcoma, Including 4 Cases Treated by Carbon Ion Radiotherapy"],"prefix":"10.1159","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-8829","authenticated-orcid":false,"given":"Takahito","family":"Negishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Matsunobu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7956-2190","authenticated-orcid":false,"given":"Makoto","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryouhei","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Kusano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9159-493X","authenticated-orcid":false,"given":"Nobuki","family":"Furubayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Shioyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichiro","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0042-3321","authenticated-orcid":false,"given":"Nokitaka","family":"Setsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motonobu","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2015.08.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.559"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.1.21"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620x.86b1.14032"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2006.04.008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0360-3016(00)00568-x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpsurg.2013.04.004"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:40:47Z","timestamp":1745422847000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000521504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3,1]]},"published-print":{"date-parts":[[2022,3,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000521504","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,16]]}}}