{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:34:02Z","timestamp":1765233242862,"version":"3.40.5"},"reference-count":21,"publisher":"S. Karger AG","issue":"12","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Myelodysplastic\/myeloproliferative neoplasm, unclassifiable (MDS\/MPN-U) is a poorly characterized entity among overlap myeloid syndromes. Recent studies have shown heterogeneous mutational profiles in this group being able to subclassify them into entities closely related to the more well-established disorders under the umbrella term of the MDS\/MPN group. Recurrent cytogenetic alterations are, nonetheless, rare in MDS\/MPN-U. Here, for the first time, we report a case of MDS\/MPN-U with a t(X;17)(q28;q21) chromosomal rearrangement leading to the &lt;i&gt;KANSL1-MTCP1&lt;\/i&gt; fusion gene. <\/jats:p>","DOI":"10.1159\/000521509","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T22:00:37Z","timestamp":1642456837000},"page":"564-568","source":"Crossref","is-referenced-by-count":2,"title":["MDS\/MPN-Unclassifiable with t(X;17)(q28;q21) and &lt;b&gt;&lt;i&gt;KANSL1-MTCP1\/CMC4&lt;\/i&gt;&lt;\/b&gt; Fusion Gene"],"prefix":"10.1159","volume":"161","author":[{"given":"Peter","family":"Molony","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-4914","authenticated-orcid":false,"given":"Adam C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamini","family":"Selvarajah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-7562","authenticated-orcid":false,"given":"Ali","family":"Sakhdari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-848473"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.07.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-015-0009-y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02256.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v92.2.368.414k39_368_373"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx163"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107069200"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22840"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v87.5.1923.1923"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.133"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004229"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.125"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20495"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2002.826"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110107"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.579221"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.04.034"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-553800"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-014-1670-3"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:40:48Z","timestamp":1745422848000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000521509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":21,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,2,10]]},"published-print":{"date-parts":[[2022,2,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000521509","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"type":"print","value":"1424-8581"},{"type":"electronic","value":"1424-859X"}],"subject":[],"published":{"date-parts":[[2021]]}}}