{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:03:36Z","timestamp":1777680216344,"version":"3.51.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> The objective of this study is to assess the long-term effectiveness of a treat-and-extend (T&amp;E) anti-vascular endothelial growth factor regimen in patients with neovascular age-related macular degeneration who remain on T&amp;E and those switched from once-monthly (OM) dosing to T&amp;E (OM-T&amp;E). <b><i>Methods:<\/i><\/b> In this 12-month extension of the 2-year CANTREAT study, patients received intravitreal ranibizumab 0.5 mg in a T&amp;E regimen. Main outcome measures included mean change in best-corrected visual acuity (BCVA) from baseline and from month 24 to month 36; percentages of patients who gained \u22655, \u226510, or \u226515 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters or lost \u22655, \u226510, or \u226515 letters from baseline and from month 24 to month 36; and number of injections administered from baseline and from month 24 to month 36 for both groups. <b><i>Results:<\/i><\/b> Of the 139 patients (73 T&amp;E, 66 OM-T&amp;E) in the extension, 121 (68 T&amp;E, 53 OM-T&amp;E) completed 36 months. Mean (standard deviation [SD]) BCVA changes from baseline to the extension last visit (month 33\u201336) were +6.6 (11.4) letters in the T&amp;E group and +4.8 (14.3) letters in the OM-T&amp;E group, representing maintenance of 24-month gains. The mean (SD) numbers of injections during the extension were 7.3 (2.7) for T&amp;E and 7.1 (2.8) for OM-T&amp;E. <b><i>Discussion\/Conclusion:<\/i><\/b> These findings suggest that after 36 months of treatment, the mean BCVA improvement achieved at 24 months is maintained for both the patients exclusively treated with the T&amp;E regimen and those that switched to T&amp;E after 24 months in the OM regimen. <\/jats:p>","DOI":"10.1159\/000521517","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T22:00:33Z","timestamp":1640901633000},"page":"230-238","source":"Crossref","is-referenced-by-count":2,"title":["Long-Term Efficacy of a Treat-and-Extend Regimen with Ranibizumab in Patients with Neovascular Age-Related Macular Disease: An Open-Label 12-Month Extension to the CANTREAT Study"],"prefix":"10.1159","volume":"245","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0348-5096","authenticated-orcid":false,"given":"Peter J.","family":"Kertes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-1857","authenticated-orcid":false,"given":"Tom","family":"Sheidow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6747-3473","authenticated-orcid":false,"given":"Geoff","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Greve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan J.","family":"Galic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the CANTREAT Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-314422"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.10.040"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.03.046"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2562-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2016.0125"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2018.24.2-a.s3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-017-0451-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001142"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4051079"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.11.031"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.02.024"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.09.011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13522"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:40:52Z","timestamp":1745422852000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000521517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,30]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,6,20]]},"published-print":{"date-parts":[[2022,6,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000521517","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.17705927","asserted-by":"subject"}]},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,30]]}}}