{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T23:20:01Z","timestamp":1775776801577,"version":"3.50.1"},"reference-count":49,"publisher":"S. Karger AG","issue":"10","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Papillary craniopharyngiomas (PCPs) represent a rare histological type of craniopharyngiomas (CPs) usually involving the hypothalamus. This study systematically analyzes the clinical-anatomical correlation between tumor topography and symptoms related to hypothalamic dysfunction in the largest series of PCPs ever gathered. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; From 5,346 CP reports published from 1856 to 2021, we selected 350 well-described cases of the squamous-papillary type. Clinical presentation, tumor topography, severity of hypothalamic adhesion, patient outcome, and tumor recurrence were thoroughly analyzed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; PCPs predominantly occur in adult (96.3%), male (61.7%) patients presenting with headache (63.4%), visual alterations (56.2%), and psychiatric disturbances (50.4%). Most PCPs are solid (50%), round (72%) lesions that occupy the third ventricle (3V, 94.8%) and show low-risk severity adhesions to the hypothalamus (66.8%). Two major topographical categories can be found: strictly 3V (57.5%), growing above an intact 3V floor, and not-strictly or infundibulo-tuberal (32.9%), expanding at the infundibulum and\/or tuber cinereum. The hypothalamic syndrome predominated among strictly 3V PCPs (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001). Psychiatric symptoms (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) and high-risk hypothalamic attachments (&lt;i&gt;p&lt;\/i&gt; = 0.031) related to unfavorable postoperative outcomes among patients treated from 2006 onwards. The not-strictly 3V topography was identified as the major predictor of high-risk hypothalamic attachments (71.2% correctly predicted), which, along with incomplete tumor removal (&lt;i&gt;p&lt;\/i&gt; = 0.018), underlies the higher tumor recurrence of this topography (&lt;i&gt;p&lt;\/i&gt; = 0.001). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; This systematic review evidences that PCP topography is a major determinant of hypothalamic-related symptoms, type of hypothalamic attachments, and tumor recurrence rate. Accurate preoperative definition of PCP-hypothalamus relationships is essential for the judicious, safe management of these complex lesions. <\/jats:p>","DOI":"10.1159\/000521652","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T22:00:43Z","timestamp":1640728843000},"page":"941-965","source":"Crossref","is-referenced-by-count":21,"title":["Papillary Craniopharyngioma: A Type of Tumor Primarily Impairing the Hypothalamus \u2013 A Comprehensive Anatomo-Clinical Characterization of 350 Well-Described Cases"],"prefix":"10.1159","volume":"112","author":[{"given":"Ruth","family":"Prieto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2492-7372","authenticated-orcid":false,"given":"Laura","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3114-0474","authenticated-orcid":false,"given":"Jos\u00e9 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