{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T19:32:01Z","timestamp":1775331121831,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Introduction: The pathophysiology of migraine has been researched incessantly, and it has been suggested that calcitonin gene-related peptide (CGRP) is associated with migraine attacks. CGRP receptor blockers are attracting attention as potential agents for migraine prevention and treatment of acute episodes. This meta-analysis aimed to assess the effects of available CGRP receptor antagonists, focusing on their therapeutic doses for acute migraine treatment. Methods: We systematically searched MEDLINE and Embase from inception to March 27, 2021, for English-language publications using the keywords \u201cmigraine\u201d and \u201ccalcitonin gene-related peptide\u201d; the searches were limited to human studies. Results: Five studies that focused on examining the effects of CGRP receptor antagonists on acute migraine treatment met the eligibility criteria for this meta-analysis. A pooled analysis demonstrated that CGRP receptor antagonists significantly increased freedom from pain (odds ratio [OR] = 2.066, 95% confidence interval [CI] 1.766\u20132.418, I2 = 0%) and from bothersome symptoms in general (OR = 1.606, 95% CI = 1.408\u20131.830, I2 = 0%); reduced the intensity of pain (OR = 1.791, 95% CI = 1.598\u20132.008, I2 = 0%); and increased freedom from nausea (OR = 1.361, 95% CI = 1.196\u20131.548, I2 = 0%) compared to a placebo. Conclusions: CGRP receptor antagonists are effective for acute migraine treatment and are expected to be used clinically as emerging therapeutic agents.<\/jats:p>","DOI":"10.1159\/000521697","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T17:00:36Z","timestamp":1643648436000},"page":"195-201","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of Calcitonin Gene-Related Peptide Receptor Antagonists for Migraine Treatment: A Meta-Analysis"],"prefix":"10.1159","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-1894","authenticated-orcid":false,"given":"Kyoungjune","family":"Pak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7592-2921","authenticated-orcid":false,"given":"Jiyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gha-Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Wook","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13300"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30435-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12651"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280213"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330109"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/298240a0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0003-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(85)90050-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00795"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-020-00997-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/head.13601"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01264-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01301-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.medidd.2020.100053"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2008.01097.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0974-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413500727"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06711-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420938652"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.4.1401"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12591"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/head.13402"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-603934\/v1"}],"updated-by":[{"DOI":"10.1159\/000530830","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000}}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ene\/article-pdf\/85\/3\/195\/4021556\/000521697.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ene\/article-pdf\/85\/3\/195\/4021556\/000521697.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:43:08Z","timestamp":1745408588000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000521697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,5,10]]},"published-print":{"date-parts":[[2022,5,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000521697","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.1159\/000530830","asserted-by":"object"}]},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}