{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:38:53Z","timestamp":1771043933105,"version":"3.50.1"},"reference-count":9,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> The aim of this study was to systematically review the literature and to perform meta-analyses on full-field electroretinography (ffERG) between healthy controls and age-related macular degeneration (AMD) to map the extent of retinal dysfunction. <b><i>Summary:<\/i><\/b> We systematically searched 11 databases on 3 March 2021. Eligible studies had to measure retinal function using ffERG in eyes with AMD and in healthy controls. We extracted data on a-wave and b-wave function in dark- and light-adapted ffERG and calculated summary estimates on differences between eyes with AMD and controls using weighted mean differences (WMD). Subgroup analyses were made for early and late AMD. Six studies (<i>n<\/i> = 481 eyes) were eligible for review (301 with any AMD, 180 controls). For dark-adapted data, any AMD was associated with reduced a-wave amplitude (WMD: \u221217.16 \u03bcV; 95% CI: \u221231.79 to \u22122.52 \u03bcV; <i>p<\/i> = 0.02) and b-wave amplitude (WMD: \u221228.70 \u03bcV; 95% CI: \u221251.40 to \u22126.01 \u03bcV; <i>p<\/i> = 0.01). For light-adapted data, any AMD was associated with longer a-wave implicit time (WMD: 0.92 ms; 95% CI: 0.12\u20131.72 ms; <i>p<\/i> = 0.02), reduced b-wave amplitude (WMD: \u221213.26 \u03bcV; 95% CI: \u221218.64 to \u22127.88 \u03bcV; <i>p<\/i> &#x3c; 0.0001), and longer b-wave implicit time (WMD: 0.69 ms; 95% CI: 0.30\u20131.08 ms; <i>p<\/i> = 0.0006). Subgroup analyses found that these changes were only statistically significant in eyes with late AMD, not early AMD. <b><i>Key Messages:<\/i><\/b> Reduced retinal function on ffERG is present in eyes with AMD, in particular those with late AMD. These findings suggest that AMD is a pan-retinal disease with AMD-associated photoreceptor dysfunction beyond the macula. <\/jats:p>","DOI":"10.1159\/000521834","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T22:00:48Z","timestamp":1641938448000},"page":"195-203","source":"Crossref","is-referenced-by-count":6,"title":["Full-Field Electroretinography Changes Associated with Age-Related Macular Degeneration: A Systematic Review with Meta-Analyses"],"prefix":"10.1159","volume":"245","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0667-6514","authenticated-orcid":false,"given":"Thomas Richard Johansen","family":"Forshaw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6620-5365","authenticated-orcid":false,"given":"Yousif","family":"Subhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sten","family":"Andr\u00e9asson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben Lykke","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14571"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.04.014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0392"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12194"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0019"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050331"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s1568-1637(02)00007-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2018.06.016"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:44:27Z","timestamp":1745423067000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000521834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,6,20]]},"published-print":{"date-parts":[[2022,6,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000521834","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.18153350","asserted-by":"subject"}]},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}