{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:03:06Z","timestamp":1785045786143,"version":"3.55.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Genomics"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Polycystic ovary syndrome (PCOS) is a common heterogeneous disorder characterized by chronic anovulation, infertility, polycystic ovaries, and hyperandrogenic signs. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to determine the association of luteinizing hormone\/chorionic gonadotropin hormone receptor LHCGR polymorphism (rs2293275) with oligomenorrhea, amenorrhea, hirsutism, acne, infertility, LH, LH\/FSH ratio, and body mass index (BMI) among PCOS females. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This genetic case-control study recruited 55 PCOS and 55 control females, diagnosed based on the Rotterdam criteria. LH and FSH were measured by the Roche cobas c 502 automated analyzer. Genotypic analysis was carried out using the polymerase chain reaction-restriction fragment length polymorphism and restriction endonuclease digestion. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; BMI was higher for PCOS patients (28.5 \u00b1 6.59) compared to controls (25.1 \u00b1 5.77), and ovulatory dysfunction was seen among 90% of PCOS females. Oligomenorrhea was common in PCOS (73%), and hirsutism and acne were detected in PCOS (80% and 40%; respectively). LH \u226510 were recoded among 51%, while LH\/FSH \u22651.5 was recorded among 33% PCOS females. There is a statistical difference between rs2293275 polymorphism in the AG genotype between PCOS patients and controls. PCOS patients have a significantly higher mean LH level compared to controls (8.36 \u00b1 4.86 and 5.67 \u00b1 2.51, respectively) and showed higher LH\/FSH value (1.46 \u00b1 0.81) compared to (0.87 \u00b1 0.30) controls. GG and AG genotypes of LHCGR showed statistically significant higher LH (8.22 \u00b1 4.11; 9.02 \u00b1 3.87) and LH\/FSH values (1.57 \u00b1 0.56; 1.64 \u00b1 0.89) compared to controls. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; LHCGR (rs2293275) GA and GG genetic variants could modulate the hormonal levels of PCOS LH levels and the LH\/FSH ratio and associated with hirsutism, oligomenorrhea, BMI, and LH\/FSH ratio as risk factors. <\/jats:p>","DOI":"10.1159\/000521971","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:00:37Z","timestamp":1648587637000},"page":"89-97","source":"Crossref","is-referenced-by-count":12,"title":["A Case-Control Study of the Luteinizing Hormone Level in Luteinizing Hormone Receptor Gene (rs2293275) Polymorphism in Polycystic Ovarian Syndrome Females"],"prefix":"10.1159","volume":"25","author":[{"given":"Manar Fayiz","family":"Atoum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Mahamad","family":"Alajlouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-3830","authenticated-orcid":false,"given":"Foad","family":"Alzoughool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.12.013"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/59380"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.10.060"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02587.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.05.003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/23723548.2014.955999"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(95)00115-g"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1457"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/13102818.2017.1423246"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126505"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2014.895982"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2014.0249"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2018.77615"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S266320"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/19396368.2019.1595217"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.107858"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew218"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.103011"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2014.5000"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-41"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-992925"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13934"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2017.12.007"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s43042-019-0031-4"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.9790\/0853-1601012023"}],"container-title":["Public Health Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/521971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:45:52Z","timestamp":1745423152000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000521971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":25,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2022,5,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000521971","archive":["Portico"],"relation":{},"ISSN":["1662-4246","1662-8063"],"issn-type":[{"value":"1662-4246","type":"print"},{"value":"1662-8063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}