{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:00:00Z","timestamp":1793412000502,"version":"4.5.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Objective:<\/i><\/b> This study aimed to study the effect of steroid treatment on new-onset sensorineural hearing loss (SNHL) in subjects presenting shortly after an audiometry-confirmed acute acoustic trauma (AAT) injury. <b><i>Study Design:<\/i><\/b> This is a case-control study. <b><i>Methods:<\/i><\/b> We identified healthy military personnel who presented with AAT injury to the Israeli Defense Forces Medical Corps Otolaryngology\/Audiology Services during 2016\u20132020. Patients were nonrandomly allocated to a treatment arm, where they received steroids (prednisone, 1 mg\/kg, 60 mg maximal daily dose), administered for either \u22657 days or &#x3c;7 days, or to a control arm, in which no treatment was offered besides loud noise avoidance. Audiometries were conducted within 7 days following the AAT and within 1 month later. We compared changes in bone conduction (BC) and air conduction (AC) thresholds at 2\u20138 kHz. <b><i>Results:<\/i><\/b> Of the 263 enrolled subjects, 137 (52%) received steroids and 126 (48%) received no treatment. Subjects who were treated early (&#x3c;24 h) with high-dose steroids and for \u22657 days demonstrated significantly better hearing outcomes, compared with the nontreatment group. Subjects in the steroids group demonstrated 13\u201314 dB average improvement in BC thresholds at 3 and 4 kHz (<i>p<\/i> = 0.001) and additional 7\u20138 dB average improvement in AC thresholds at 6 and 8 kHz, compared with the nontreatment group (<i>p<\/i> &#x3c; 0.0001). These observations were more compelling in patients who initially presented with worse hearing losses (&#x3e;35 dB). No statistically significant differences were observed in AC\/BC pure tone average between the two groups. <b><i>Conclusions:<\/i><\/b> Early oral steroids are recommended in AAT injuries and were shown to improve hearing outcomes within 1 month. <\/jats:p>","DOI":"10.1159\/000522051","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T22:00:39Z","timestamp":1646172039000},"page":"312-320","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy of Oral Steroids for Acute Acoustic Trauma"],"prefix":"10.1159","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-9636","authenticated-orcid":false,"given":"Elchanan","family":"Zloczower","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Tsur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shir","family":"Hershkovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4937-2628","authenticated-orcid":false,"given":"Nir","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Marom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usaa579"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001784"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S002221511900121X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.17.1658"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3282efa641"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7597"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3138\/jmvfh.2017-0034"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usx112"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1121\/1.5132710"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e3181987080"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002760"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000259195"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/1463-1741.165067"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688433"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001071"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s0194-5998(03)01586-9"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.16043"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080\/00016480801901634"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:46:52Z","timestamp":1745423212000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000522051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,7,19]]},"published-print":{"date-parts":[[2022,7,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000522051","archive":["Portico"],"relation":{},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"value":"1420-3030","type":"print"},{"value":"1421-9700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}