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Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Dev"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Sex development is an intricate and crucial process in all vertebrates that ensures the continued propagation of genetic diversity within a species, and ultimately their survival. Perturbations in this process can manifest as disorders\/differences of sex development (DSD). Various transcriptional networks have been linked to development of the gonad into either male or female, which is actively driven by a set of genes that function in a juxtaposed manner and is maintained through the developmental stages to preserve the final sexual identity. One such identified gene is Chromobox homolog 2 (&lt;i&gt;CBX2&lt;\/i&gt;), an important ortholog of the Polycomb group (PcG) proteins, that functions as both chromatin modifier and highly dynamic transactivator. &lt;i&gt;CBX2&lt;\/i&gt; was shown to be an essential factor for gonadal development in mammals, as genetic variants or loss-of-function of &lt;i&gt;CBX2&lt;\/i&gt; can cause sex reversal in mice and humans. Here we will provide an overview of &lt;i&gt;CBX2&lt;\/i&gt;, its biological functions at molecular level, and the CBX2-dependent transcriptional landscape in gonadal development and DSD. <\/jats:p>","DOI":"10.1159\/000522164","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T22:00:32Z","timestamp":1646863232000},"page":"162-170","source":"Crossref","is-referenced-by-count":10,"title":["&lt;b&gt;&lt;i&gt;CBX2&lt;\/i&gt;&lt;\/b&gt; in DSD: The Quirky Kid on the Block"],"prefix":"10.1159","volume":"16","author":[{"given":"Dirk","family":"Hart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-0769","authenticated-orcid":false,"given":"Daniel","family":"Rodr\u00edguez 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