{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:32:32Z","timestamp":1747193552045,"version":"3.40.5"},"reference-count":9,"publisher":"S. Karger AG","issue":"7","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> In severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related respiratory failure, the prognostic value of clinically based or blood-gas-based respiratory indexes is unclear. <b><i>Objectives:<\/i><\/b> We aimed to assess the prognostic value of Respiratory Index (RI, oxygen saturation [SpO2]\/respiratory rate [RR]), RR-oxygenation index (ROX, SpO2\/fraction of inspired oxygen [FiO2]\/RR), partial pressure of oxygen (PaO2)\/FiO2 ratio (P\/F), or standard PaO2\/FiO2 ratio (<sub>ST<\/sub>P\/F) at admission and of their variation during hospitalization in SARS-CoV-2-related respiratory failure. <b><i>Methods:<\/i><\/b> In 100 consecutive patients hospitalized due to SARS-CoV-2-related respiratory failure, we assessed the association of RI, ROX, P\/F and <sub>ST<\/sub>P\/F, and death; secondary outcome was the composite of 7-day death or intensive care unit (ICU) admission. <b><i>Results:<\/i><\/b> ROX &#x3c;3.85 at admission (hazard ratio [HR] 2.95, 95% confidence interval [CI] 1.29\u20136.77) and decreasing RI or P\/F during hospitalization (RI: HR 1.05, 95% CI: 1.00\u20131.09; P\/F: HR 1.01, 95% CI: 1.00\u20131.02) were predictors of in-hospital death. RI \u22643.8, ROX &#x3c;3.85, and P\/F &#x3c;100 at admission were predictors for death or ICU admission (RI: HR 3.77, 95% CI: 1.30\u201310.98; ROX: HR 4.56, 95% CI: 1.90\u201310.96; P\/F: HR 7.37, 95% CI: 1.59\u201334.2). The decrease of RI (HR 1.14, 95% CI: 1.03\u20131.25), ROX (HR 1.45, 95% CI: 1.11\u20131.88), P\/F (HR 1.08, 95% CI: 1.01\u20131.15), or <sub>ST<\/sub>P\/F (HR 1.05, 95% CI: 1.01\u20131.08) during hospitalization was associated with 7-day death or ICU admission. <b><i>Conclusions:<\/i><\/b> In patients with SARS-CoV-2-related respiratory failure, easy-to-calculate clinically based respiratory indexes at admission and their variation during hospital stay can be used to assess and monitor the risk for death or ICU admission. <\/jats:p>","DOI":"10.1159\/000522275","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T22:00:42Z","timestamp":1647381642000},"page":"632-637","source":"Crossref","is-referenced-by-count":8,"title":["Early Variation of Respiratory Indexes to Predict Death or ICU Admission in Severe Acute Respiratory Syndrome Coronavirus-2-Related Respiratory Failure"],"prefix":"10.1159","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9252-1297","authenticated-orcid":false,"given":"Giorgio","family":"Maraziti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Becattini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202004-1076ED"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0337-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199701000-00010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.63.5.793"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu262"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v035.i09"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202008-3142ed"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2008.tb01825.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1081CP"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522275","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:49:15Z","timestamp":1745423355000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000522275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":9,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,1]]},"published-print":{"date-parts":[[2022,6,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000522275","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19361297","asserted-by":"subject"}]},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2022]]}}}