{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:25:49Z","timestamp":1774581949250,"version":"3.50.1"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: This study aimed to evaluate the impact of chronological and biological age on perioperative complications and survival after radical nephroureterectomy (RNU). Elderly patients with upper-tract urothelial carcinoma might be overtreated by RNU. Methods: We retrospectively analyzed patients undergoing RNU. To evaluate the perioperative risk, patients were divided into four groups (&lt;75; 75\u201379; 80\u201384; \u226585 years). The endpoints are perioperative complications and survival (overall survival [OS]). We calculated a risk score including chronological and biological age (Eastern cooperative oncology group performance status). Statistical analysis was performed by Kruskal-Wallis, Mann-Whitney U, \u03c72, log-rank, and Breslow tests. Results: 194 patients were included in the study. Median follow-up was 25.5 months. Elderly cohorts \u22652 presented a higher number of days in intensive care unit following RNU (p &lt; 0.001). Complication rates increased from cohort 1\u20134 with rates of 48.8%; 55.2%; 92.0%; 85.7% (p &lt; 0.001). Median survival was 115, 55, 28, and 20 months for cohorts 1, 2, 3, and 4, respectively. The combined risk score revealed a significant 5-year OS benefit for patients with score 0 (82.3%) compared to score 1 (46.0%) and score 2 (15.0%; p &lt; 0.001). Discussion\/Conclusion: We evaluated the impact of chronological and biological age on perioperative complications and survival after RNU. A combined risk score of chronological and biological age correlates with survival after RNU. <\/jats:p>","DOI":"10.1159\/000522295","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T22:00:34Z","timestamp":1647036034000},"page":"72-79","source":"Crossref","is-referenced-by-count":6,"title":["Age and ECOG Performance Status as Predictors of Survival of Patients with Upper Urinary Tract Urothelial Carcinoma Undergoing Radical Nephroureterectomy"],"prefix":"10.1159","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9971-4411","authenticated-orcid":false,"given":"Lennert","family":"Eismann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Bohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7895-7070","authenticated-orcid":false,"given":"Alexander","family":"Buchner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozefina","family":"Casuscelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-9398","authenticated-orcid":false,"given":"Yannic","family":"Volz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Weinhold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"W\u00fclfing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-5058","authenticated-orcid":false,"given":"Raphaela","family":"Waidelich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-9460","authenticated-orcid":false,"given":"Christian G.","family":"Stief","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6150-776X","authenticated-orcid":false,"given":"Boris","family":"Schlenker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Severin","family":"Rodler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09675.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2009.07.020"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S220221"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10708"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2017.09.013"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-016-0595-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3909\/riu0691"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11550.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2017.08.012"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/519897"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089\/end.2015.0248"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/uin\/article-pdf\/107\/1\/72\/3952763\/000522295.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/uin\/article-pdf\/107\/1\/72\/3952763\/000522295.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:49:33Z","timestamp":1745423373000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000522295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,11]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,23]]},"published-print":{"date-parts":[[2023,1,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000522295","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,11]]}}}