{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:57:23Z","timestamp":1791212243163,"version":"4.1.0"},"reference-count":235,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Innate Immun"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Citrullination of proteins is crucial for the formation of neutrophil extracellular traps (NETs) \u2013 strands of nuclear DNA expulsed in the extracellular environment along with antimicrobial proteins in order to halt the spread of pathogens. Paradoxically, NETs may be immunogenic and contribute to inflammation. It is known that for the externalization of DNA, a group of enzymes called peptidyl arginine deiminases (PADs) is required. Current research often looks at citrullination, NET formation, PAD overexpression, and extracellular DNA (ecDNA) accumulation in chronic diseases as separate events. In contrast, we propose that citrullination can be viewed as the primary mechanism of autoimmunity, for instance by the formation of anti-citrullinated protein antibodies (ACPAs) but also as a process contributing to chronic inflammation. Therefore, citrullination could be at the center, connecting and impacting multiple inflammatory diseases in which ACPAs, NETs, or ecDNA have already been documented. In this review, we aimed to highlight the importance of citrullination in the etiopathogenesis of a number of chronic diseases and to explore the diagnostic, prognostic, and therapeutic potential of the citrullination-NET axis. <\/jats:p>","DOI":"10.1159\/000522331","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T22:00:32Z","timestamp":1646863232000},"page":"393-417","source":"Crossref","is-referenced-by-count":18,"title":["The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases"],"prefix":"10.1159","volume":"14","author":[{"given":"Martin","family":"Maronek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Gardlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/182186a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.01.013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000452"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1588-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-1920-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23620"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-2797"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4161\/pri.22380"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.029405"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2174\/1389450116666150202160954"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2013.07.003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208795200"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.9b00225"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb799"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041351"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201006052"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701391"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311150"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000221"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1714371"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy215"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2018.10.003"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29914"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001310"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.004"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2015.10.014"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2019.01.024"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239126"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.012211"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1000-7"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00034"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00244"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1136\/ard.23.4.302"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6182.97"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2018.05.004"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X21989868"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1116-9"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170769"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203947"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1002\/art.37911"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1002\/art.39412"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1002\/art.40066"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1002\/art.22983"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072049"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1002\/art.27570"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1002\/art.23596"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15038750"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213818"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-10-801"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1713112114"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1002\/art.41189"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005580"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139388"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.584116"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23662"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.01.003"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2337"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01451.x"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003627"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100838"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA119.001700"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.6b00634"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1159\/000489020"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12099"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03591-y"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12171"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.10.827"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12002"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.96"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12542"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01175.x"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2020.vol34.0015"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12288"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1556-7"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192365"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13117"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12727"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000460"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8080275"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-09-0710"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz132"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12715"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17218054"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0381-3"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaa095"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00435.2010"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5937"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00024"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106583"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048777"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-014-9766-x"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-014-3607-6"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010081"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.593316"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29919"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2582-1"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.07.005"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.7165"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11169"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2020.07.009"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00254.2016"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2009.06.007"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1208-6"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-012-9414-z"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-013-9481-9"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.06.002"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.001180"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2004.03.005"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0812-z"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1038\/srep36362"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.10.028"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3887"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071419"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.02.034"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12892"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0863"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-019-0850-0"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-017-0666-5"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.15.1617"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005743107"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04544.x"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300498"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.04.021"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005861"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003377"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.1002\/art.39938"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165651"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315267"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-412197"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14339"},{"key":"ref133","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20479-x"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-018-0073-2"},{"key":"ref135","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301627"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1641749"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8064"},{"key":"ref138","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2019.1662678"},{"key":"ref139","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.134796"},{"key":"ref140","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303312"},{"key":"ref141","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01680"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.312494"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0781OC"},{"key":"ref144","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00002"},{"key":"ref145","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.06.011"},{"key":"ref146","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0912437"},{"key":"ref147","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.06.008"},{"key":"ref148","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12800"},{"key":"ref149","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.09.033"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02536"},{"key":"ref151","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2407-8"},{"key":"ref152","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148142"},{"key":"ref153","doi-asserted-by":"publisher","DOI":"10.1186\/cc11442"},{"key":"ref154","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00365.2013"},{"key":"ref155","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000741"},{"key":"ref156","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111888"},{"key":"ref157","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-741298"},{"key":"ref158","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045427"},{"key":"ref159","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0538-5"},{"key":"ref160","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00591-7"},{"key":"ref161","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03896-1"},{"key":"ref162","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-587709"},{"key":"ref163","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700639"},{"key":"ref164","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800314"},{"key":"ref165","doi-asserted-by":"publisher","DOI":"10.1159\/000448808"},{"key":"ref166","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.04.009"},{"key":"ref167","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.138873"},{"key":"ref168","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa475"},{"key":"ref169","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306035"},{"key":"ref170","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.101030"},{"key":"ref171","doi-asserted-by":"publisher","DOI":"10.1186\/cc11466"},{"key":"ref172","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/614518"},{"key":"ref173","doi-asserted-by":"publisher","DOI":"10.1159\/000440975"},{"key":"ref174","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.11.018"},{"key":"ref175","doi-asserted-by":"publisher","DOI":"10.1186\/cc13908"},{"key":"ref176","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303062"},{"key":"ref177","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016080925"},{"key":"ref178","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1549-x"},{"key":"ref179","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218548"},{"key":"ref180","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/643189"},{"key":"ref181","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149956"},{"key":"ref182","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1448.014"},{"key":"ref183","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-001078"},{"key":"ref184","doi-asserted-by":"publisher","DOI":"10.1159\/000445546"},{"key":"ref185","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.08.006"},{"key":"ref186","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00089.2019"},{"key":"ref187","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00569.2017"},{"key":"ref188","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.08.014"},{"key":"ref189","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30481-1"},{"key":"ref190","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10039"},{"key":"ref191","doi-asserted-by":"publisher","DOI":"10.2478\/s11658-007-0025-y"},{"key":"ref192","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400106"},{"key":"ref193","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117300"},{"key":"ref194","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1425"},{"key":"ref195","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-5728(01)00312-5"},{"key":"ref196","doi-asserted-by":"publisher","DOI":"10.1021\/jm800891n"},{"key":"ref197","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20102"},{"key":"ref198","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12620"},{"key":"ref199","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.05.007"},{"key":"ref200","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00540"},{"key":"ref201","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311427570"},{"key":"ref202","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2011.11.009"},{"key":"ref203","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2013.05.004"},{"key":"ref204","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2010.090170"},{"key":"ref205","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0679-z"},{"key":"ref206","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700748"},{"key":"ref207","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3349-06.2006"},{"key":"ref208","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.000729"},{"key":"ref209","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511421055"},{"key":"ref210","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.108"},{"key":"ref211","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010520"},{"key":"ref212","doi-asserted-by":"publisher","DOI":"10.1021\/jm301755q"},{"key":"ref213","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.03.006"},{"key":"ref214","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6659960"},{"key":"ref215","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0909142"},{"key":"ref216","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00211"},{"key":"ref217","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.01.003"},{"key":"ref218","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3913"},{"key":"ref219","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20431"},{"key":"ref220","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20120025"},{"key":"ref221","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.03.004"},{"key":"ref222","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9061301"},{"key":"ref223","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71239-9"},{"key":"ref224","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.169158"},{"key":"ref225","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(74)91639-0"},{"key":"ref226","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00204"},{"key":"ref227","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax8847"},{"key":"ref228","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.621477"},{"key":"ref229","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.0160"},{"key":"ref230","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3178"},{"key":"ref231","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.08.001"},{"key":"ref232","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1938"},{"key":"ref233","doi-asserted-by":"publisher","DOI":"10.1186\/1757-7241-22-21"},{"key":"ref234","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkab001"},{"key":"ref235","doi-asserted-by":"publisher","DOI":"10.1080\/02713680600991437"}],"container-title":["Journal of Innate Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522331","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:49:49Z","timestamp":1745423389000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000522331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":235,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,9,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000522331","archive":["Portico"],"relation":{},"ISSN":["1662-811X","1662-8128"],"issn-type":[{"value":"1662-811X","type":"print"},{"value":"1662-8128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}