{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:32:37Z","timestamp":1780597957771,"version":"3.54.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Purpose:<\/i><\/b> Monitoring the sublingual and oral microcirculation (SM-OM) using hand-held vital microscopes (HVMs) has provided valuable insight into the (patho)physiology of diseases. However, the microvascular anatomy in a healthy population has not been adequately described yet. <b><i>Methods:<\/i><\/b> Incident dark field-based HVM imaging was used to visualize the SM-OM. First, the SM was divided into four different fields; Field-a (between incisors-lingua), Field-b (between the canine-first premolar-lingua), Field-c (between the first-second premolar-lingua), Field-d (between the second molar-wisdom teeth-lingua). Second, we investigated the buccal area, lower and upper lip. Total\/functional vessel density (TVD\/FCD), focus depth (FD), small vessel mean diameters (SVMDs), and capillary tortuosity score (CTS) were compared between the areas. <b><i>Results:<\/i><\/b> Fifteen volunteers with a mean age of 29 \u00b1 6 years were enrolled. No statistical difference was found between the sublingual fields in terms of TVD (<i>p<\/i> = 0.30), FCD (<i>p<\/i> = 0.38), and FD (<i>p<\/i> = 0.09). SVMD was similar in Field-a, Field-b, and Field-c (<i>p<\/i> = 0.20\u20130.30), and larger in Field-d (<i>p<\/i> &#x3c; 0.01, <i>p<\/i> = 0.015). The CTS of the buccal area was higher than in the lips. <b><i>Conclusion:<\/i><\/b> The sublingual area has a homogenous distribution in TVD, FCD, FD, and SVMD. This study can be a description of the normal microvascular anatomy for future researches regarding microcirculatory assessment. <\/jats:p>","DOI":"10.1159\/000522394","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T22:00:33Z","timestamp":1647900033000},"page":"199-208","source":"Crossref","is-referenced-by-count":10,"title":["Morphologic Mapping of the Sublingual Microcirculation in Healthy Volunteers"],"prefix":"10.1159","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-8907","authenticated-orcid":false,"given":"G\u00f6ksel","family":"G\u00fcven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00fchre","family":"Uz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-881X","authenticated-orcid":false,"given":"Matthias P.","family":"Hilty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Bileceno\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0218akir","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Ince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Ince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/cc14726"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06722-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200109-016oc"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/10739680802461935"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0473-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001369"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-015-0040-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jml.2007.12.005"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jml.2012.11.001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-015-9708-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.07.006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00298.2015"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000335"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000634"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2009.04.004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1364\/oe.15.015101"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.1.74"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-005-0050-0"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:50:25Z","timestamp":1745423425000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000522394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,7,19]]},"published-print":{"date-parts":[[2022,7,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000522394","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19390340","asserted-by":"subject"}]},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"value":"1018-1172","type":"print"},{"value":"1423-0135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}