{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:39:52Z","timestamp":1789195192143,"version":"build-2803163510"},"reference-count":3,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiorenal Med"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background and Aims:<\/i><\/b> We investigated the association between serum cystatin-C (Cys-C) levels and cardiovascular events in patients with acute coronary syndrome (ACS). <b><i>Methods:<\/i><\/b> Data of 1,100 patients from the prospective parent study were included. Patients hospitalized for ACS were divided into 4 groups based on quartiles (Q) of Cys-C levels (mg\/L) within 24 h of admission: Q1, \u22640.82; Q2, 0.82 &#x3c; estimated level \u22640.95; Q3, 0.95&#x3c; estimated level \u22641.12; and Q4, &#x3e;1.12. The primary endpoint of this study was all-cause mortality, and the secondary endpoint was composite of all-cause mortality, nonfatal myocardial infarction, nonfatal stroke, unstable angina pectoris, or ischemia-driven revascularization. <b><i>Results:<\/i><\/b> During a median observation period of 4.0 years, the primary endpoint was noted in 5, 12, 18, and 36 patients in Q1\u2013Q4, respectively, with corresponding incidence rates of 1.8%, 4.4%, 6.5%, and 13.5%, respectively (<i>p<\/i> &#x3c; 0.0001 for difference among 4 groups). This association persisted even after adjusting for patient characteristics and other laboratory results at baseline (<i>p<\/i> = 0.04). A stepwise increase in the incidence rate of the secondary endpoint with an incline in Cys-C levels was observed in the nonadjusted model (26.6%, 33.3%, 32.3%, and 39.1% in Q1\u2013Q4, respectively; <i>p<\/i> = 0.01) but not in the adjusted model (<i>p<\/i> = 0.3). No difference was observed in the incidence rate of nonfatal myocardial infarction (<i>p<\/i> = 0.89), nonfatal stroke (<i>p<\/i> = 0.3), unstable angina pectoris (<i>p<\/i> = 0.49), and ischemia-driven revascularization (<i>p<\/i> = 0.47) with an incline in Cys-C levels. <b><i>Conclusion:<\/i><\/b> Elevated Cys-C levels were associated with increased all-cause mortality but not cardiovascular events other than mortality in ACS patients. <\/jats:p>","DOI":"10.1159\/000522412","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T22:00:40Z","timestamp":1644444040000},"page":"20-28","source":"Crossref","is-referenced-by-count":6,"title":["Elevated Cystatin-C Levels Are Associated with Increased Mortality in Acute Coronary Syndrome Patients: An HIJ-PROPER Sub-Analysis"],"prefix":"10.1159","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4263-0580","authenticated-orcid":false,"given":"Takashi","family":"Saito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-8603","authenticated-orcid":false,"given":"Hiroyuki","family":"Arashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0967-0978","authenticated-orcid":false,"given":"Junichi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.644286"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.119669"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.1.71"}],"container-title":["Cardiorenal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:50:38Z","timestamp":1745423438000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000522412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":3,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,3,22]]},"published-print":{"date-parts":[[2022,3,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000522412","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19144529","asserted-by":"subject"}]},"ISSN":["1664-3828","1664-5502"],"issn-type":[{"value":"1664-3828","type":"print"},{"value":"1664-5502","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}