{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:42:19Z","timestamp":1785782539269,"version":"3.56.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> To diagnose hypoalbuminemia in newborns, it is essential to establish a definition applicable to those with a different gestational age (GA) and clinical conditions. A positive correlation between serum albumin levels and GA has been reported, but the study was limited to small numbers of newborns. We therefore investigated the GA-dependent reference ranges for serum albumin levels using cord venous blood (UC-Alb levels) from a large number of newborns delivered at a tertiary perinatal center. <b><i>Methods:<\/i><\/b> Albumin levels were assessed in 2,917 newborns at 22\u201341 weeks of GA after exclusion of those with congenital disorders. Linear regression analysis was used to correlate GA and UC-Alb levels. After calculation of the percentile values of UC-Alb levels for each week of GA, the distributions were approximated by the least-squares method. To validate the determined linear approximation of the 5%ile value, the UC-Alb levels in newborns with hydrops fetalis and gastroschisis were used. <b><i>Results:<\/i><\/b> A significant positive correlation between GA and UC-Alb levels was found (<i>r<\/i><sub>s<\/sub> = 0.701, <i>p<\/i> &#x3c; 0.001, respectively). The distribution of the 5%ile of UC-Alb levels (<i>Y<\/i>) by GA (<i>X<\/i>) was approximated as a straight line (<i>Y<\/i> = 0.062 \u00d7 <i>X<\/i> + 0.326, <i>R<\/i><sup>2<\/sup> = 0.951). Among the 59 and 18 newborns with hydrops fetalis and gastroschisis, 51 (86.4%) and 15 (83.3%), respectively, were below the line. <b><i>Conclusions:<\/i><\/b> We established GA-dependent reference ranges for serum albumin levels, which may be useful to accurately diagnose hypoalbuminemia in newborns. <\/jats:p>","DOI":"10.1159\/000522502","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T22:00:57Z","timestamp":1647468057000},"page":"327-333","source":"Crossref","is-referenced-by-count":13,"title":["Gestational Age-Dependent Reference Ranges for Albumin Levels in Cord Serum"],"prefix":"10.1159","volume":"119","author":[{"given":"Toshihiko","family":"Ikuta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2871-4000","authenticated-orcid":false,"given":"Sota","family":"Iwatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3435-8687","authenticated-orcid":false,"given":"Takahiro","family":"Okutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S102819"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2017.07.009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(98)00070-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3468(89)80717-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.11.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050917"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004208.pub2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000446043"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.7.657"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(90)90082-t"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-8981(99)00158-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(73)90102-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.18.6.25"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.02.028"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-011-2921-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103436"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105068"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.04.003"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.127"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522502","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:51:25Z","timestamp":1745423485000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000522502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,5,17]]},"published-print":{"date-parts":[[2022,5,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000522502","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19367927","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}