{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:06:09Z","timestamp":1759824369201,"version":"3.40.5"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; An effective and well-tolerated topical treatment of Raynaud\u2019s phenomenon is needed. The aim of this pilot study was to determine change in skin temperature and self-reported warmth perception from topical rosemary essential oil in patients with systemic sclerosis and secondary Raynaud\u2019s phenomenon. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; Twelve patients with progressive systemic sclerosis and Raynaud\u2019s phenomenon were consecutively enrolled in an open-label pilot study at a university outpatient rheumatology clinic. Each patient received an application of olive oil to both hands as a control and 3 h later an application of a 10% essential oil of &lt;i&gt;Rosmarinus officinalis&lt;\/i&gt; L. Clinical severity and subjective warmth perception were assessed; skin temperature was measured by infrared thermography. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Skin temperature increased significantly after both olive oil and rosemary oil but differences between oils did not reach significance. Self-reported warmth perception increased after rosemary oil but not after olive oil. No adverse effects were observed. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Topical rosemary essential oil increased warmth perception in patients with systemic sclerosis-related Raynaud\u2019s phenomenon but did not increase finger skin temperature more than the olive oil control. <\/jats:p>","DOI":"10.1159\/000522507","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T22:00:40Z","timestamp":1644444040000},"page":"242-248","source":"Crossref","is-referenced-by-count":5,"title":["Topical &lt;b&gt;&lt;i&gt;Rosmarinus officinalis&lt;\/i&gt;&lt;\/b&gt; L. in Systemic Sclerosis-Related Raynaud\u2019s Phenomenon: An Open-Label Pilot Study"],"prefix":"10.1159","volume":"29","author":[{"given":"Jan","family":"Vagedes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8385-6861","authenticated-orcid":false,"given":"J\u00f6rg","family":"Henes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Deckers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4019-9531","authenticated-orcid":false,"given":"Katrin","family":"Vagedes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6621-7219","authenticated-orcid":false,"given":"Silja","family":"Kuderer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Helmert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tido","family":"von Schoen-Angerer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,2,9]]},"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:51:27Z","timestamp":1745423487000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000522507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,6,21]]},"published-print":{"date-parts":[[2022,6,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000522507","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19145804","asserted-by":"subject"}]},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"type":"print","value":"2504-2092"},{"type":"electronic","value":"2504-2106"}],"subject":[],"published":{"date-parts":[[2022]]}}}