{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:32:55Z","timestamp":1747193575844,"version":"3.40.5"},"reference-count":22,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> Invasive breast carcinoma with a choriocarcinomatous pattern (IBC-CP) is extremely rare, and its molecular basis is yet unclear. The choriocarcinomatous pattern is characterized by the biphasic arrangement of multinucleated syncytiotrophoblast-like cells around clusters of monotypic tumor cells in a hemorrhagic background, along with \u03b2-human chorionic gonadotropin (\u03b2-hCG) expression. The differentiation of IBC-CP from metastatic choriocarcinoma of the breast (MC-B) is difficult due to the histologic similarity. <b><i>Methods:<\/i><\/b> Based on a literature review and our own case, the clinicopathologic differences between IBC-CP patients (<i>n<\/i> = 17) and MC-B patients (<i>n<\/i> = 8) were analyzed. Moreover, in our case of IBC-CP, next-generation sequencing (NGS) comparative analysis was conducted for both choriocarcinomatous and invasive breast carcinoma (IBC) components. <b><i>Results:<\/i><\/b> Compared to the MC-B patients, the IBC-CP patients were older (<i>p<\/i> &#x3c; 0.001) and less frequently had past histories of gestational trophoblastic disease\/pregnancy\/abortion (<i>p<\/i> = 0.001) and distant metastases (<i>p<\/i> = 0.005). Our case, a 49-year-old female patient, presented with masses in the right breast and axilla. Following neoadjuvant chemotherapy, a radical mastectomy found an 8.5-cm-sized tumor. Microscopically, multinucleated syncytiotrophoblast-like cells were observed around mononuclear tumor cells with hemorrhage and necrosis. Some tumor cells showed \u03b2-hCG immunopositivity, which was compatible with IBC-CP. NGS results showed a missense mutation in exon 5 of the <i>TP53<\/i> gene in both the choriocarcinomatous and IBC components. Meanwhile, copy number loss in the <i>PTEN<\/i> gene was only identified in the choriocarcinomatous components. <b><i>Conclusion:<\/i><\/b> The present IBC-CP case is triple-negative breast cancer with <i>TP53<\/i> mutation. The <i>PTEN<\/i> gene may be associated with choriocarcinomatous differentiation. Obtaining a medical history is mandatory to exclude metastatic lesions. <\/jats:p>","DOI":"10.1159\/000522621","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T21:00:32Z","timestamp":1648674032000},"page":"359-369","source":"Crossref","is-referenced-by-count":3,"title":["Clinicopathologic and Molecular Characteristics of and Diagnostic Dilemmas in Invasive Breast Carcinoma with Choriocarcinomatous Pattern apropos a New Case: A Literature Review with New Findings"],"prefix":"10.1159","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-2094","authenticated-orcid":false,"given":"Sun-Young","family":"Jun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nara","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soyeon","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Joon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Suk","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2009.00882.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000325443"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20485"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.anndiagpath.2004.01.003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4741.2002.08411.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1590\/s1516-31802001000400009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1990.tb01554.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198112000-00006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-013-0392-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.3_supplement.01840s53"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000326291"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/s0748-7983(95)97675-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(91)90039-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(81)90049-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5858\/2010-0334-RSR1.1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.105"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.02.010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(84)90016-6"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/his.12681"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-017-0246-y"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000512006"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.11.005"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522621","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/522621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:52:44Z","timestamp":1745423564000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000522621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,12,13]]},"published-print":{"date-parts":[[2022,12,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000522621","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19453385","asserted-by":"subject"}]},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"type":"print","value":"1015-2008"},{"type":"electronic","value":"1423-0291"}],"subject":[],"published":{"date-parts":[[2022]]}}}