{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:33:15Z","timestamp":1747193595003,"version":"3.40.5"},"reference-count":12,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Programmed cell death (PD)\/PD-ligands (PD-Ls) pathway plays an important role in the regulation of physiologic immune response. Several cancers, including lymphoma exhibit abnormal PD-1\/PD-Ls expression, which may contribute to treatment failure, progression, and inferior outcomes. PD-1\/PD-Ls expression has predominantly been described in B-cell lymphoma; such data in peripheral T-cell lymphoma (PTCL) is limited. We described PD-1\/PD-Ls expression patterns and associations with clinical characteristics and outcomes, in patients with systemic PTCLs. Correlation between PD-1\/PD-Ls expression and outcomes was analyzed in patients who received lymphoma-specific therapy. PD-1\/PD-Ls expression was observed across all common PTCL histologies at different proportions (PD-1 0%\u201376.9%, PD-L1 38.5%\u201362.5%, and PD-L2 62.5%\u2013100%) with PD-1 being highly expressed in angioimmunoblastic T-cell lymphoma. Baseline characteristics were comparable between PD-1\/PD-Ls expression status. Of 47 patients who received lymphoma-specific therapy, outcomes were similar across all PD-L1\/PD-L2 subgroups. In the Cox proportional hazard analysis, treatment response was the only factor associated with survival outcomes. However, PD-1\/PD-Ls expression, either in lymphoma or stroma, was not a predictor for survival outcomes. In conclusion, differential PD-1\/PD-Ls expressions were observed among various histological PTCL subtypes. In this study, we were unable to demonstrate an association between PD-1\/PD-Ls expression, clinical characteristics, treatment response, and outcomes of PTCL patients. <\/jats:p>","DOI":"10.1159\/000523873","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T16:28:11Z","timestamp":1646238491000},"page":"542-552","source":"Crossref","is-referenced-by-count":0,"title":["Expression of Programmed Cell Death-1 and Programmed Cell Death Ligands in Nodal Peripheral T-Cell Lymphoma: Expression Pattern and Potential Prognostic Relevance"],"prefix":"10.1159","volume":"145","author":[{"given":"Thiti","family":"Asawapanumas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nichthida","family":"Tangnantachai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narittee","family":"Sukswai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thammathorn","family":"Assanasen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantiya","family":"Chanswangphuwana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panisinee","family":"Lawsut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantana","family":"Polprasert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7912-1996","authenticated-orcid":false,"given":"Ponlapat","family":"Rojnuckarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udomsak","family":"Bunworasate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-8681","authenticated-orcid":false,"given":"Kitsada","family":"Wudhikarn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112049"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00961"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27172"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017012534"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-016-0201-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.019133"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.10.029"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v126.23.3899.3899"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000531"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3266-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.03.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v126.23.1461.1461"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/523873","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/523873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:55:39Z","timestamp":1745423739000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000523873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,9,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000523873","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19289561","asserted-by":"subject"}]},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2022]]}}}