{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:31:54Z","timestamp":1758706314572,"version":"3.40.5"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Objective:<\/i><\/b> Second- and third-trimester SARS-CoV-2 infections may have an increased risk of obstetric complications. However, data on first-trimester infections are scarce. We sought to characterize the clinical and inflammatory presentations and pregnancy outcomes of first-trimester infections. <b><i>Methods:<\/i><\/b> A population-based multicenter study including 817 singleton pregnancies with SARS-CoV-2 serologic testing at 8\u201314 weeks between March and May 2020. Blood count, uterine artery Doppler, and pregnancy-associated plasma protein A (PAPP-A) were performed in all women. Placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), IL-6, and ferritin were determined in positive women. Obstetric outcomes were evaluated. <b><i>Results:<\/i><\/b> The prevalence of first-trimester infection was 15.2% (<i>n<\/i> = 124). 72.6% of positive women were asymptomatic. Symptomatic women had higher rates of lymphopenia (1.91 \u00d7 10<sup>9<\/sup>\/L vs. 2.16 \u00d7 10<sup>9<\/sup>\/L, <i>p<\/i> = 0.017) and increased levels of IL-6 (9.1% vs. 1.2%, <i>p<\/i> = 0.051), but lower rates of decreased ferritin (6.3% vs. 19.8%, <i>p<\/i> = 0.015). PAPP-A was higher in symptomatic women compared with asymptomatic and negative women (1.44 [IQR 0.90\u20131.82] vs. 1.08 [IQR 0.66\u20131.61] <i>p<\/i> = 0.014, vs. 1.08 [IQR 0.77\u20131.55] <i>p<\/i> = 0.019, respectively). Obstetric outcomes were not increased. <b><i>Conclusions:<\/i><\/b> First-trimester SARS-CoV-2 infections are mostly asymptomatic, with a mild increase of inflammatory markers in symptomatic women. Obstetric complications were not increased, but PAPP-A levels were higher in symptomatic women. <\/jats:p>","DOI":"10.1159\/000523974","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T22:00:32Z","timestamp":1646863232000},"page":"67-76","source":"Crossref","is-referenced-by-count":13,"title":["First-Trimester SARS-CoV-2 Infection: Clinical Presentation, Inflammatory Markers, and Obstetric Outcomes"],"prefix":"10.1159","volume":"49","author":[{"given":"Cristina","family":"Trilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Crovetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7422-5240","authenticated-orcid":false,"given":"F\u00e0tima","family":"Crispi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Gratacos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Llurba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the KidsCorona Pregnancy COVID-19 Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90592.2008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.163428"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1570029"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.64"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12355"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31714-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2019.06.005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.11.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2007.09.001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1313"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2020-0369"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/523974","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/523974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:56:39Z","timestamp":1745423799000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000523974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,5,16]]},"published-print":{"date-parts":[[2022,5,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000523974","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19328777","asserted-by":"subject"}]},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2022]]}}}