{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:32:56Z","timestamp":1789011176965,"version":"build-2803163510"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>The &lt;i&gt;c-ros oncogene 1 (ROS1)&lt;\/i&gt; fusion gene is a rare genomic alteration detected in nearly 1\u20132% of lung adenocarcinomas. The major partner genes of &lt;i&gt;ROS1&lt;\/i&gt; include &lt;i&gt;CD74&lt;\/i&gt;, &lt;i&gt;SDC4&lt;\/i&gt;, and &lt;i&gt;EZR&lt;\/i&gt;. Here, we report a case of &lt;i&gt;MYH9-ROS1&lt;\/i&gt; fusion gene-positive lung adenocarcinoma, a rare &lt;i&gt;ROS1&lt;\/i&gt; fusion gene. The patient was a woman in her 40s who was diagnosed with advanced primary lung adenocarcinoma after a thorough examination. Initial genetic testing conducted using mediastinal lymph node biopsy specimens collected by endobronchial ultrasound-guided transbronchial needle aspiration revealed no driver gene mutations, including the &lt;i&gt;ROS1&lt;\/i&gt; fusion gene. The patient was treated with four courses of immunochemotherapy. As the disease worsened, another genetic test was conducted using FoundationOne&lt;sup&gt;\u00ae&lt;\/sup&gt; CDx, and the &lt;i&gt;MYH9-ROS1&lt;\/i&gt; fusion gene was detected. Multiple lung metastases disappeared after the administration of entrectinib; the response persisted up to a year. Adverse events of rash, dysgeusia, and peripheral edema were observed, and the patient required temporary drug interruption; however, we were able to continue entrectinib following a short-term drug interruption. This is the first report on the effectiveness of entrectinib against lung adenocarcinoma with the rare &lt;i&gt;MYH9-ROS1&lt;\/i&gt; fusion gene. <\/jats:p>","DOI":"10.1159\/000524071","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:01:15Z","timestamp":1648760475000},"page":"376-381","source":"Crossref","is-referenced-by-count":5,"title":["Rare &lt;b&gt;&lt;i&gt;MYH9-ROS1&lt;\/i&gt;&lt;\/b&gt; Fusion Gene-Positive Lung Adenocarcinoma Showing Response to Entrectinib Treatment: A Case Study"],"prefix":"10.1159","volume":"15","author":[{"given":"Takeshi","family":"Tsuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Ishizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,3,31]]},"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:57:46Z","timestamp":1745423866000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,5,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000524071","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,31]]}}}