{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:29:55Z","timestamp":1785540595822,"version":"3.56.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> The aim of the study was to determine the effect of a maternal docosahexaenoic acid (DHA) supplementation during lactation, compared with a placebo, on the neonatal growth profile of breastfed very preterm infants. <b><i>Methods:<\/i><\/b> Preterm infants\u2019 growth profile, growth velocity from birth to 36 weeks\u2019 postmenstrual age (PMA), and growth at 36 weeks\u2019 PMA were pre-specified secondary outcomes of a randomized placebo-controlled trial conducted in 16 Canadian neonatal intensive care units (2015\u20132018). Lactating mothers who delivered before 29 weeks\u2019 gestation were given 1.2 g of DHA daily or a placebo within 72 h of delivery and up to 36 weeks\u2019 PMA. Analyses were performed using a linear regression model with generalized estimating equations. <b><i>Results:<\/i><\/b> 461 mothers and their 528 infants (DHA, <i>N<\/i> = 273; placebo, <i>N<\/i> = 255) were included with mean gestational age of 26.5 weeks (standard deviation [SD] = 1.6); 275 (52.1%) were males; mean birth weight was 895 g (SD = 240). DHA interaction with sex was significant on weight profile (interaction <i>p<\/i> &#x3c; 0.001), weight velocity (interaction <i>p<\/i> = 0.05), and weight at 36 weeks\u2019 PMA (interaction <i>p<\/i> = 0.02). Females in the DHA group gained more weight compared to the placebo group (mean difference [MD], 52.6 g [95% confidence interval [CI]: 24.5\u201380.8], <i>p<\/i> &#x3c; 0.001). Weight velocity was significantly higher in females of the DHA group (MD, 3.4 g\/kg\/day [95% CI: 0.6\u20136.2], <i>p<\/i> = 0.02). At 36 weeks\u2019 PMA, the weight of males in the DHA group was significantly smaller (MD, \u221288.9 g [95% CI: \u2212166.2 to \u221211.6], <i>p<\/i> = 0.02). <b><i>Conclusion:<\/i><\/b> DHA positively affected female infants\u2019 neonatal weight profile and velocity and negatively affected male infants\u2019 weight at 36 weeks\u2019 PMA. <\/jats:p>","DOI":"10.1159\/000524147","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T21:00:39Z","timestamp":1649797239000},"page":"377-385","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Maternal Docosahexaenoic Acid Supplementation on Very Preterm Infant Growth: Secondary Outcome of a Randomized Clinical Trial"],"prefix":"10.1159","volume":"119","author":[{"given":"Georgina","family":"Angoa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-9546","authenticated-orcid":false,"given":"Etienne","family":"Pronovost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissatou Bintou Khairy Thilor","family":"Ndiaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal 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