{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:49:42Z","timestamp":1781596182450,"version":"3.54.5"},"reference-count":9,"publisher":"S. Karger AG","issue":"7","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> Lung volume reduction coil (LVR-coil) treatment provides a minimally invasive treatment option for severe emphysema patients which has been studied in multiple clinical trials. <b><i>Objectives:<\/i><\/b> The aim of the study was to assess the effect of LVR-coil treatment on pulmonary function, quality of life, and exercise capacity using individual participant data. <b><i>Method:<\/i><\/b> PubMed, Web of Science, and EMBASE were searched until May 17, 2021. Prospective single-arm and randomized controlled trials that evaluated the effect of LVR-coil treatment on forced expiratory volume in 1 s (FEV<sub>1<\/sub>), residual volume (RV), St. George Respiratory Questionnaire (SGRQ) total score, and\/or 6-min walk distance (6MWD) and were registered in an official clinical trial database were eligible for inclusion. Individual patient data were requested, and a linear mixed effects model was used to calculate overall treatment effects. <b><i>Results:<\/i><\/b> Eight trials were included in the final analysis, representing 680 individual patients. LVR-coil treatment resulted in a significant improvement in FEV1 at 3- (0.09 L [95% confidence interval (95% CI): 0.06\u20130.12]) and 6-month follow-up (0.07 L [95% CI: 0.03\u20130.10]), a significant reduction in RV at 3- (\u22120.45L [95% CI: \u22120.62 to \u22120.28]), 6- (\u22120.33L [95% CI: \u22120.52 to \u22120.14]), and 12-month follow-up (\u22120.36L [95% CI: \u22120.64 to \u22120.08]), a significant reduction in SGRQ total score at 3- (\u221212.3 points [95% CI: \u221215.8 to \u22128.8]), 6- (\u221210.1 points [95% CI: \u221212.8 to \u22127.3]), and 12-month follow-up (\u22129.8 points [95% CI: \u221215.0 to \u22124.7]) and a significant increase in 6MWD at 3-month follow-up (38 m [95% CI: 18\u201358]). <b><i>Conclusions:<\/i><\/b> LVR-coil treatment in emphysema patients results in sustained improvements in pulmonary function and quality of life and shorter lived improvements in exercise capacity. Since the owner of this LVR-coil has decided to stop the production and newer generations LVR-coils are currently being developed, these results can act as a reference for future studies and clinical guidance. <\/jats:p>","DOI":"10.1159\/000524148","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T21:00:48Z","timestamp":1649710848000},"page":"697-705","source":"Crossref","is-referenced-by-count":24,"title":["Bronchoscopic Lung Volume Reduction Coil Treatment for Severe Emphysema: A Systematic Review and Meta-Analysis of Individual Participant Data"],"prefix":"10.1159","volume":"101","author":[{"given":"Sharyn A.","family":"Roodenburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-9673","authenticated-orcid":false,"given":"Jorine E.","family":"Hartman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebtan","family":"Desl\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-2506","authenticated-orcid":false,"given":"Felix J.F.","family":"Herth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Klooster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank C.","family":"Sciurba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-4638","authenticated-orcid":false,"given":"Pallav L.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arschang","family":"Valipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2533-6160","authenticated-orcid":false,"given":"Zaid","family":"Zoumot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9555-3422","authenticated-orcid":false,"given":"Dirk-Jan","family":"Slebos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2009.03.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30431-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000490193"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1081\/copd-200053377"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00219111"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1081\/copd-200050513"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0730"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000362522"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13816"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:58:37Z","timestamp":1745423917000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":9,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,1]]},"published-print":{"date-parts":[[2022,6,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000524148","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19572499","asserted-by":"subject"}]},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}