{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T23:09:11Z","timestamp":1749683351928,"version":"3.40.5"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> Turner syndrome (TS) results from a complete or partial loss of the X chromosome and affects 25\u201350 per 100,000 females. These individuals have characteristic neurocognitive and psychological profiles with an increased lifetime prevalence of mood disorders, such as depression and anxiety. Consensus guidelines recommend the use of psychometrically robust tools to screen for these conditions [Eur J Endocrinol. 2017;177(3):G1\u2013G70 and Gynecol Endocrinol. 2004;19(6):313\u20139]. We propose a sustainable and informative approach to routine anxiety screening in individuals with TS and describe the prevalence of anxiety, genotype-phenotype associations, and impact of comorbidities on anxiety. <b><i>Methods:<\/i><\/b> We pilot the use of a self-administered version of the validated Pediatric, Parent Proxy, and Adult Patient-Reported Outcomes Measurement Information System (PROMIS\u00ae) Anxiety tool during routine visits to the Cincinnati Children\u2019s Hospital Medical Center (CCHMC) TS clinic from October 2019 to March 2020. <b><i>Results:<\/i><\/b> Ninety-two eligible TS females, ages 8\u201362 years, received the PROMIS\u00ae Anxiety measure. Elevated anxiety scores, \u22651 standard deviation above the <i>T<\/i>-score mean, were present in 65% of patients (38% mild, 19% moderate, and 8% severe). Results were discussed during the clinic visit, and referral for further evaluation and treatment was offered. There was no apparent genotype-phenotype association among females with anxiety; however, there appeared to be elevated anxiety symptoms (<i>T<\/i>-score &#x3e;60) in those with hearing deficits and also in individuals with three or more medical comorbidities. Of the 55% of patients who filled out the acceptability survey, 88% found the process helpful and \u223c50% felt that screening should be performed at least every 6 months. <b><i>Conclusion:<\/i><\/b> Our study demonstrated a high prevalence of anxiety symptoms within a cohort of 92 females with TS. In alignment with current guidelines, these findings indicate the importance of routine neuropsychological assessments for timely recognition and subsequent management of anxiety, especially as milder presentations may otherwise go unnoticed. We have shown that screening tools, such as the PROMIS\u00ae Anxiety measure, can be easily utilized by nonmental health care providers (i.e., endocrinologists) who may see TS patients more frequently and be able to initiate impactful discussions surrounding mental health and further referral to subspecialists for expert management. <\/jats:p>","DOI":"10.1159\/000524169","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T22:00:33Z","timestamp":1647900033000},"page":"68-75","source":"Crossref","is-referenced-by-count":6,"title":["Improving Anxiety Screening in Patients with Turner Syndrome"],"prefix":"10.1159","volume":"95","author":[{"given":"Eirene","family":"Alexandrou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Corathers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Gutmark-Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-456X","authenticated-orcid":false,"given":"Lori","family":"Casnellie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-245X","authenticated-orcid":false,"given":"Melissa","family":"Gerstle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Tatum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8064-6404","authenticated-orcid":false,"given":"Jane","family":"Khoury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Backeljauw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31679"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200112000-00003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-019-01549-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31687"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3182255301"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.12.1374"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15489.2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/1073191116685809"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.05.001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2011.533405"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.131.4.483"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/cch.12710"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31823b6296"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:58:49Z","timestamp":1745423929000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,5,10]]},"published-print":{"date-parts":[[2022,5,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000524169","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2022]]}}}