{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:26:07Z","timestamp":1745468767529,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background and Objectives:<\/i><\/b> The Canadian TIA Score has been verified as a good predictive tool for subsequent stroke risk in Caucasian patients; however, it had insufficient external verification of other races. We aimed to validate the Canadian TIA Score in Chinese patients and compared it with ABCD<sup>2<\/sup> for subsequent stroke risk after transient ischemic attack (TIA). <b><i>Methods:<\/i><\/b> The Third China National Stroke Registry (CNSR-III) was a nationwide, multicenter prospective registry recruiting consecutive patients with acute ischemic stroke or TIA within 7 days of the onset from August 2015 to March 2018. The Canadian TIA Score was verified in patients diagnosed with TIA from the CNSR-III (<i>N<\/i> = 1,184). The outcomes were subsequent stroke at 7 days, 14 days\/discharge, 3 months, and 1 year. Outcomes were recorded by face-to-face assessment or telephone interview. The prognostic performance of the scoring system was assessed by the area under the receiver operator characteristic curve (AUC). <b><i>Results:<\/i><\/b> Of 1,184 TIA patients (mean [IQR] age, 61.00 [53.00\u201369.00] years; 413 women [34.88%]), there were 40 patients (3.38%) having subsequent stroke within 7 days, 45 (3\u00b780%) within 14 days\/hospitalization, 66 (5\u00b757%) within 3 months, and 100 (8\u00b745%) within 1 year. The Canadian TIA Score (AUC 0 63\u20130\u00b768) seemed to be a better prognostic score of stroke risk than the ABCD<sup>2<\/sup> score (AUC 0\u00b761\u20130\u00b762), although no significant differences were noted. In the subgroup of atypical TIA, the Canadian TIA Score showed significantly stronger predictivity than the ABCD<sup>2<\/sup> score within 7 days (0.80 [0.62\u20130.98] vs. 0.52 [0.30\u20130.73]; difference in AUC, 0.28 [0.03\u20130.53]; <i>p<\/i>, 0.026), and marginal significantly stronger predictivity within 1 year (0.71 [0.61\u20130.80] vs. 0.58 [0.48\u20130.68]; difference in AUC, 0.12 [\u22120.01 to 0.25]; <i>p<\/i>, 0.06). <b><i>Conclusion:<\/i><\/b> The Canadian TIA Score might be a better prognostic score than the ABCD<sup>2<\/sup> score for post-TIA stroke risk, especially in patients with atypical TIA. <\/jats:p>","DOI":"10.1159\/000524264","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T21:00:31Z","timestamp":1651784431000},"page":"735-743","source":"Crossref","is-referenced-by-count":1,"title":["Validation of the Canadian TIA Score to Predict Subsequent Stroke Risk in Chinese TIA Patients"],"prefix":"10.1159","volume":"51","author":[{"given":"Chengyuan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.171"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187067.93321.fa"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp020891"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.20.10.1407"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31961-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.15.4.723"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.62.8_suppl_6.s20"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90086-i"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.20.2.300"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:00:15Z","timestamp":1745424015000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":9,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,12,22]]},"published-print":{"date-parts":[[2023,1,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000524264","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19713715","asserted-by":"subject"}]},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"type":"print","value":"1015-9770"},{"type":"electronic","value":"1421-9786"}],"subject":[],"published":{"date-parts":[[2022]]}}}