{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:05:45Z","timestamp":1758629145841,"version":"3.40.5"},"reference-count":8,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Data were retrieved from medical records of a single-center cohort of 75 patients with LS. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood. <\/jats:p>","DOI":"10.1159\/000524350","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:00:44Z","timestamp":1648760444000},"page":"286-290","source":"Crossref","is-referenced-by-count":1,"title":["Focal Epilepsy in Individuals with Laron Syndrome"],"prefix":"10.1159","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1257-0062","authenticated-orcid":false,"given":"Lotem","family":"Goldberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Laron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liora","family":"Kornreich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-4083","authenticated-orcid":false,"given":"Oded","family":"Scheuerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadassa","family":"Goldberg-Stern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dror","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2015.08.004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2012.02.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1460499"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1191"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/000992280504400906"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/0883073810376245"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2003.12.008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0024"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:01:26Z","timestamp":1745424086000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,8,4]]},"published-print":{"date-parts":[[2022,8,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000524350","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2022]]}}}