{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:26:11Z","timestamp":1745468771483,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Dengue infection is a significant public health concern that no specific treatment is available. Extracorporeal plasmapheresis or plasma filtration is a treatment option for severe cases with complications. However, the commercial adsorption devices mainly contained size-exclusive porous beads to adsorb the plasma proteins nonselectively. Methods: We developed a 1:50 simulated circuit for dengue virus-specific adsorption using a flavivirus-specific (4G2) antibody entrapped into the alginate bead. Results: The reduction ratios of the viral titer after 3 h of continuous run were 63.00 \u00b1 1.21%, and 93.97 \u00b1 1.27% measured by reverse transcription qPCR, and plaque titration, respectively. No specific adsorption was observed with Enterovirus A71 or Escherichia coli bacteria. Conclusion: This study is a proof-of-concept for the potential use of a dengue virus-specific adsorption column in the 1:50 simulated circuit. The system could be applied to various clinical platforms by substituting target-specific antibodies. <\/jats:p>","DOI":"10.1159\/000524387","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T21:00:31Z","timestamp":1651784431000},"page":"60-67","source":"Crossref","is-referenced-by-count":0,"title":["An Extracorporeal Plasma Filtration Column with Specific Binding to Dengue Virions"],"prefix":"10.1159","volume":"52","author":[{"given":"Sasiwimon","family":"Thonghong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pat","family":"Sinananpat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanittha","family":"Chatsuwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nattachai","family":"Srisawat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Numpon","family":"Insin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saran","family":"Salakij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siwaporn","family":"Boonyasuppayakorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2149\/tmh.2011-S10"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00035-09"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003783"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6803098"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw609"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2016.11.010"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/473137"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150487"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.12.016"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.15.105"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05291"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.10.130"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2149\/tmh.2011-S03"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00116-07"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000508647"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2017.01.017"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-1031-3_38"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/bpu\/article-pdf\/52\/1\/60\/3961219\/000524387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/bpu\/article-pdf\/52\/1\/60\/3961219\/000524387.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:01:49Z","timestamp":1745424109000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,27]]},"published-print":{"date-parts":[[2023,1,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000524387","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"type":"print","value":"0253-5068"},{"type":"electronic","value":"1421-9735"}],"subject":[],"published":{"date-parts":[[2022,5,5]]}}}