{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:11:47Z","timestamp":1782511907012,"version":"3.54.5"},"reference-count":17,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> In asthma, exhaled nitric oxide (F<sub>E<\/sub>NO) is a clinically established biomarker of airway T2 inflammation and an indicator for anti-inflammatory therapy. <b><i>Objectives:<\/i><\/b> The aim of the study was to identify, in an observational real-world cross-sectional study, the main characteristics of patients with asthma as classified by their F<sub>E<\/sub>NO level. <b><i>Method:<\/i><\/b> We stratified 398 patients with stable mild-to-severe asthma according to F<sub>E<\/sub>NO level as low (\u226425 ppb) versus elevated (&#x3e;25 ppb), subdividing the latter into two subgroups: moderately elevated (26\u201350 ppb) versus very high F<sub>E<\/sub>NO (&#x3e;50 ppb). Clinical, functional, and blood parameters were extrapolated from patients\u2019 chart data and compared with the F<sub>E<\/sub>NO stratification. Predictors of low and elevated F<sub>E<\/sub>NO asthma were detected by logistic regression model. <b><i>Results:<\/i><\/b> Low BMI, higher blood eosinophilia, allergen poly-sensitization, the severest airflow obstruction (FEV<sub>1<\/sub>\/FVC), and anti-leukotriene use are predictors of elevated F<sub>E<\/sub>NO values in asthma, as well as persistent rhinitis and chronic rhinosinusitis with or without nasal polyps. Beyond these, younger age, more than 2 asthma exacerbations\/year, higher airflow reversibility (post-bronchodilator \u2206FEV<sub>1<\/sub>), and oral corticosteroid dependence are predictors of very high F<sub>E<\/sub>NO values. In contrast, obesity, obstructive sleep apnoea syndrome, gastroesophageal reflux disease, arterial hypertension, and myocardial infarction are predictors of low F<sub>E<\/sub>NO asthma. In our population, F<sub>E<\/sub>NO correlated with blood eosinophils, airflow obstruction, and reversibility and negatively correlated with age and BMI. <b><i>Conclusions:<\/i><\/b> Stratifying patients by F<sub>E<\/sub>NO level can identify specific asthma phenotypes with distinct clinical features and predictors useful in clinical practice to tailor treatment and improve asthmatic patients\u2019 outcomes. <\/jats:p>","DOI":"10.1159\/000524498","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T21:00:31Z","timestamp":1651784431000},"page":"746-756","source":"Crossref","is-referenced-by-count":9,"title":["Predictors of Low and High Exhaled Nitric Oxide Values in Asthma: A Real-World Study"],"prefix":"10.1159","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-0394","authenticated-orcid":false,"given":"Francesca","family":"Bertolini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5891-871X","authenticated-orcid":false,"given":"Andrea E.","family":"Sprio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Baroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Riccardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pizzimenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-5206","authenticated-orcid":false,"given":"Vitina","family":"Carriero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Arrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-0875","authenticated-orcid":false,"given":"Antonino","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-5018","authenticated-orcid":false,"given":"Fabio L.M.","family":"Ricciardolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.3.157315"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.08.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1221064"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.057"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2014.11.004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2015.36.3805"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-211540"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000599"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.022"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.02.034"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-123"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188709"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/all.14997"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2217\/thy.11.15"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228536"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.12932\/AP0322.32.1.2014"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2019.00654"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:03:13Z","timestamp":1745424193000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":17,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8,2]]},"published-print":{"date-parts":[[2022,8,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000524498","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19711900","asserted-by":"subject"}]},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}