{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:20Z","timestamp":1787017940287,"version":"build-2736575974"},"reference-count":11,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Objective:<\/i><\/b> This study aimed to detect the association between P-selectin autoantibody positive and response to steroid treatment in newly diagnosed immune thrombocytopenia (ITP) patients. <b><i>Methods:<\/i><\/b> The data from 105 newly diagnosed adult ITP patients administered with first-line of steroid treatment from October 2016 to May 2021 were retrospectively analyzed. Treatment responses were evaluated within 3 months after the onset of treatment. <b><i>Results:<\/i><\/b> Among the 105 patients, 80.00% (84\/105) of patients presented with platelet glycoprotein-specific antibody positive; 44.76% (47\/105) patients were anti-P-selectin positive, while 35.24% (37\/105) were anti-P-selectin negative. No significant difference in overall response was observed between patients who were anti-P-selectin positive and those who were anti-P-selectin negative (74.47% vs. 89.19, \u03c7<sup>2<\/sup> = 2.910, <i>p<\/i> = 0.088). But patients who were anti-P-selectin negative had significantly higher complete response rate, compared to those who were anti-P-selectin positive (72.97% vs. 48.94%, \u03c7<sup>2<\/sup> = 4,965, <i>p<\/i> = 0.026). Logistic regression analysis revealed that anti-GP IIb\/IIIa positive (OR = 3.114, <i>p<\/i> = 0.010, 95% CI: 1.313\u20137.388) and anti-P-selectin positive (OR = 0.309, <i>p<\/i> = 0.036, 95% CI: 0.127\u20130.753) were two factors that could affect patients\u2019 response. <b><i>Conclusions:<\/i><\/b> Our study found that ITP patients with anti-GP IIb\/IIIa may have a higher response to steroid treatment, but anti-P-selectin-mediated-ITP might be less responsive to steroid treatment. In adults with ITP, the presence of anti-P-selectin autoantibodies is a predictive factor for poor response to steroid treatment.<\/jats:p>","DOI":"10.1159\/000524535","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T17:00:48Z","timestamp":1649696448000},"page":"499-504","source":"Crossref","is-referenced-by-count":3,"title":["Association between P-Selectin Autoantibody Positive and Response to Steroid Treatment in Newly Diagnosed Immune Thrombocytopenia Patients"],"prefix":"10.1159","volume":"145","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Ying","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Xun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Qiu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jie","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.400"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2018089"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1179\/1607845412Y.0000000014"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000574"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.6.886"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10667"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10051004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1993.tb04669.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v69.2.570.570"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2021.107566"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04324.x"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:03:42Z","timestamp":1745409822000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,9,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000524535","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}