{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:18:06Z","timestamp":1790194686804,"version":"4.1.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> The Amplatzer and Watchman left atrial appendage closure (LAAC) devices are the two most frequently used devices for LAAC devices worldwide. This meta-analysis aimed to compare the safety and efficacy of the two devices. <b><i>Methods:<\/i><\/b> We searched the PubMed, EMBASE, and the Cochrane Library for studies up to February 6, 2022 that compared the safety and efficacy of the Amplatzer and Watchman devices. <b><i>Results:<\/i><\/b> Fifteen studies including 2,150 patients in randomized controlled trials and 2,526 patients in observational studies were included in the meta-analysis. Amplatzer device was associated with higher rates of major procedure-related complications (odds ratio [OR]: 1.99, 95% confidence interval [CI]: 1.45\u20132.74, <i>p<\/i> &#x3c; 0.0001) and device embolization (OR: 1.99, 95% CI: 1.09\u20133.64, <i>p<\/i> = 0.03). However, Amplatzer device had lower rates of total peridevice leak (PDL) (OR: 0.48, 95% CI: 0.27\u20130.83, <i>p<\/i> = 0.009), significant PDL (OR: 0.27, 95% CI: 0.12\u20130.57, <i>p<\/i> = 0.0007) and device-related thrombus (DRT) (OR: 0.67, 95% CI: 0.48\u20130.95, <i>p<\/i> = 0.02). No statistical differences were observed between the two devices in other safety and efficacy endpoints, such as pericardial effusion, cardiac tamponade, air embolism, vascular complications, ischemic stroke\/transient ischemic attack (TIA), hemorrhagic stroke, all-cause death, cardiovascular death, and bleeding. <b><i>Conclusions:<\/i><\/b> Amplatzer LAAC device was associated with higher rates of major procedure-related complications, especially in device embolization. Watchman LAAC device was associated with higher rates of PDL and DRT. There were no significant differences between two devices in ischemic stroke\/TIA, hemorrhagic stroke, all-cause death, cardiovascular death, and bleeding. <\/jats:p>","DOI":"10.1159\/000524626","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T21:00:47Z","timestamp":1650920447000},"page":"290-297","source":"Crossref","is-referenced-by-count":9,"title":["Comparison between Amplatzer and Watchman Left Atrial Appendage Closure Devices for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"147","author":[{"given":"Jianzhong","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tieniu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enlai","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.22.8.983"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00887-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY19M08_01"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.057063"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2021.100893"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26678"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2352648"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.09.051"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.33963\/kp.15864"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12316"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01814.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.01.015"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:04:24Z","timestamp":1745424264000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,7,1]]},"published-print":{"date-parts":[[2022,7,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000524626","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.19646664","asserted-by":"subject"}]},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}