{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:31:10Z","timestamp":1790947870834,"version":"4.1.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Objective:<\/i><\/b> The prevalence of phage 80\/81 <i>Staphylococcus aureus<\/i> strains, the pandemic strains that were dominant in the 1950s, had declined in the 1960s and 1970s. However, these strains have reemerged in some countries in recent years. This study investigated the antibacterial resistance, virulence, and the genetic backgrounds of CC30-MSSA isolates obtained from patients in three tertiary hospitals. <b><i>Materials and Methods:<\/i><\/b> Twenty-two CC30-MSSA isolates cultured from different clinical samples were investigated using antibiotic sensitivity testing, <i>spa<\/i> typing, multilocus sequence typing, and DNA microarray analysis. <b><i>Results:<\/i><\/b> All 22 isolates were susceptible to vancomycin (MIC \u22642 \u03bcg\/mL), teicoplanin (MIC \u22642 \u03bcg\/mL), and cefoxitin but were resistant to penicillin G (<i>n<\/i> = 22; 100.0%), tetracycline (<i>n<\/i> = 12; 54.5%), ciprofloxacin (<i>n<\/i> = 15; 68.2%), cadmium acetate (<i>n<\/i> = 22; 100%), mercuric chloride (<i>n<\/i> = 13; 59.1%), and ethidium bromide (<i>n<\/i> = 3; 13.6%). The isolates belonged to sequence type, ST30, and five <i>spa<\/i> types: t012 (<i>n<\/i> = 12; 54.5%), t019 (<i>n<\/i> = 5; 22.7%), t017 (<i>n<\/i> = 2; 9.1%), t037 (<i>n<\/i> = 2; 9.1%), and t318 (<i>n<\/i> = 1; 4.5%). All 22 isolates were positive for <i>agrIII, cap8<\/i>, <i>clfA, clfB, icaA, icaC, icaD<\/i>, <i>cna<\/i>, and staphylococcal enterotoxin gene clusters (<i>seg, sei, sem, sen, seo, seu<\/i>)<i>.<\/i> Eight isolates carried <i>lukS-PV<\/i> and <i>lukF-PV<\/i> that code for Panton-Valentine leukocidin. <b><i>Conclusion:<\/i><\/b> The current CC30-MSSA isolates share phenotypic and genotypic characteristics with the pandemic phage 80\/81 isolates that were common in the 1950s and 1960s. Continued surveillance is recommended to keep abreast of the changing epidemiology of <i>S. aureus<\/i> causing healthcare and community-associated infections. <\/jats:p>","DOI":"10.1159\/000524755","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T21:00:37Z","timestamp":1652821237000},"page":"269-275","source":"Crossref","is-referenced-by-count":3,"title":["Description of Methicillin-Susceptible <b><i>Staphylococcus aureus<\/i><\/b> Clonal Complex 30 Related to the Pandemic Phage Type 80\/81 Isolated from Patients in Three Tertiary Hospitals in Jos, North Central Nigeria"],"prefix":"10.1159","volume":"31","author":[{"given":"Unyime C.","family":"Essien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar S.","family":"Boswihi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5122-5988","authenticated-orcid":false,"given":"Nneka R.","family":"Agbakoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-7949","authenticated-orcid":false,"given":"Edet E.","family":"Udo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00134-14"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000354201"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.00768.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1139\/m56-041"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128\/aac.47.12.3926-3934.2003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2016.08.006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.10.007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2000.tb09209.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.3.1008-1015.2000"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.01986.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00048"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114276"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2019.39.2.158"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10111329"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162744"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00521-06"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/nmi2.47"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:56:34Z","timestamp":1745420194000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,7,1]]},"published-print":{"date-parts":[[2022,7,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000524755","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}