{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:44:10Z","timestamp":1781131450209,"version":"3.54.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Aim: We planned a cross-sectional investigation (study 1) and a longitudinal training intervention (study 2) to investigate whether recreational dancing affords greater neuroprotective effects against age-related neuromuscular junction (NMJ) degeneration compared to general fitness exercise training. Methods: In study 1, we recruited 19 older volunteers regularly practising dancing (older dancers [OD]) and 15 recreationally physically active older individuals (OA) and physical performance, muscle morphology, muscle function, and NMJ stability (from serum C-terminal agrin fragment [CAF] concentration) were assessed. In study 2, employing a longitudinal study design in a different cohort (composed of 37 older adults), we aimed to study whether a 6-month dancing intervention decreased CAF concentration compared to general fitness exercise training in older adults. Results: Our findings show that OD had a lower CAF concentration (suggesting an increased NMJ stability) compared to OA. This result was accompanied by superior functional performance despite no differences in muscle size. In study 2, we observed a reduction in CAF concentration only in the dancing group. Conclusion: Overall, these findings suggest that dancing is an effective training modality to promote neuroprotection and increase muscle function in healthy older individuals. <\/jats:p>","DOI":"10.1159\/000524843","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T21:00:42Z","timestamp":1653339642000},"page":"73-81","source":"Crossref","is-referenced-by-count":8,"title":["Neuromuscular Aging: A Case for the Neuroprotective Effects of Dancing"],"prefix":"10.1159","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3165-4536","authenticated-orcid":false,"given":"Martino V.","family":"Franchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Badiali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Sarto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Notger G.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Rehfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Monti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-8305","authenticated-orcid":false,"given":"Stefano","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"H\u00f6kelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Narici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-016-9641-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00044.2018"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c200029"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114310"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00164.2004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1768-z"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1113\/JP270561"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa207"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00174.2021"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.05.070"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24095"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2020.104110"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00946"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00713504"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1113\/JP271212"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2012.05.010"}],"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ger\/article-pdf\/69\/1\/73\/3953095\/000524843.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ger\/article-pdf\/69\/1\/73\/3953095\/000524843.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:57:24Z","timestamp":1745420244000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,23]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,3]]},"published-print":{"date-parts":[[2023,1,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000524843","archive":["Portico"],"relation":{},"ISSN":["0304-324X","1423-0003"],"issn-type":[{"value":"0304-324X","type":"print"},{"value":"1423-0003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,23]]}}}