{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:04:39Z","timestamp":1782320679537,"version":"3.54.5"},"reference-count":18,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Systemic inflammation response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been proposed as peripheral blood biomarkers. We compared these blood biomarkers to identify the best predictor in patients with hypopharyngeal squamous cell carcinoma (HPSCC). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We conducted a retrospective study on 304 patients with HPSCC. SIRI was divided into three groups using X-tile version 3.6.1. The optimal cut-off points for NLR, LMR, and PLR were selected through RStudio. We compared the prognostic capacity of SIRI with that of NLR, LMR, and PLR using receiver operating characteristic curves. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Smoking, cancer in the postcricoid region, lymph node metastasis (N+), extracapsular invasion, SIRI in the highest tertile (&amp;#x3e;2.80), and LMR in the lowest tertile (&amp;#x3c;5.0) may cause poor 5-year overall survival (OS) in patients with HPSCC. Local and distant recurrences may occur earlier in those with lymph node metastasis and a tumor invading beyond the mucosa layer. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; SIRI was a better predictor of OS than LMR, PLR, and NLR in HPSCC patients. SIRI in the highest tertile (&amp;#x3e;2.80) and LMR in the lowest tertile (&amp;#x3c;5.0) may cause poor 5-year OS. <\/jats:p>","DOI":"10.1159\/000524870","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T18:23:06Z","timestamp":1655403786000},"page":"453-463","source":"Crossref","is-referenced-by-count":8,"title":["The Prognostic Capacity of Systemic Inflammation Response Index, Neutrophil-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio, and Platelet-to-Lymphocyte Ratio in Patients with Hypopharyngeal Squamous Cell Carcinoma"],"prefix":"10.1159","volume":"84","author":[{"given":"Tian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyao","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ching","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00913.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000492305"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70263-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.03.010"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23567"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25324"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25075"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02160"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/ans.15480"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2019.190132"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2018.1449965"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6157-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00766"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4659048"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:57:44Z","timestamp":1745420264000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,11,24]]},"published-print":{"date-parts":[[2022,11,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000524870","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}