{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:47:28Z","timestamp":1760042848264,"version":"3.40.5"},"reference-count":8,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Extramedullary relapse of acute myeloid leukemia (AML) is not a rare event, and the FMS-like tyrosine kinase 3 (&lt;i&gt;FLT3&lt;\/i&gt;) mutation is a well-known risk factor. Gilteritinib is approved for relapsed\/refractory &lt;i&gt;FLT3&lt;\/i&gt;+ AML, but its efficacy in extramedullary relapse is still undefined. Here, we present the case of a 69-year-old woman with therapy-related nucleophosmin-1 and &lt;i&gt;FLT3&lt;\/i&gt;-internal tandem duplication (&lt;i&gt;FLT3&lt;\/i&gt;-ITD) positive AML treated with induction and consolidation with CPX-351 (liposomal daunorubicin plus cytarabine) followed by off-label azacitidine maintenance who obtained a complete remission (CR) with persistent measurable residual disease. After 19 months of CR, she experienced an isolated breast relapse of &lt;i&gt;FLT3&lt;\/i&gt;-ITD+ AML. She was started on single-agent gilteritinib, resulting in a rapid and persistent complete regression of the breast nodule. Targeted therapy with gilteritinib for relapsed\/refractory &lt;i&gt;FLT3&lt;\/i&gt;-ITD+ AML can be effective in isolated extramedullary relapse. <\/jats:p>","DOI":"10.1159\/000524878","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T21:00:37Z","timestamp":1652821237000},"page":"566-570","source":"Crossref","is-referenced-by-count":5,"title":["Gilteritinib in Isolated Breast Relapse of &lt;b&gt;&lt;i&gt;FLT3&lt;\/i&gt;&lt;\/b&gt; Positive Acute Myeloid Leukemia: A Case Report and Review of Literature"],"prefix":"10.1159","volume":"145","author":[{"given":"Giulia","family":"Arrigo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"D\u2019Ard\u00eca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesta","family":"Audisio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1666-3100","authenticated-orcid":false,"given":"Marco","family":"Cerrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Freilone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Giai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Secreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Urbino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Frairia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2016.04.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-347229"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-020-02855-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2020.0110"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200809020-00019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/JLP.JLP_114_17"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.01.009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2015.03.004"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:57:49Z","timestamp":1745420269000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,9,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000524878","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2022]]}}}