{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:36:08Z","timestamp":1776828968439,"version":"3.51.2"},"reference-count":5,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> Invasive bone biopsy to assess bone metabolism in patients with chronic kidney disease-mineral and bone disorder may be replaced by the noninvasive <sup>18<\/sup>F-NaF PET\/CT and biomarkers of bone metabolism. We aimed to compare parameters of bone turnover, mineralization, and volume assessed by bone biopsies with results derived from <sup>18<\/sup>F-NaF PET\/CT and biomarkers (bone-specific alkaline phosphatase, osteocalcin, fibroblast growth factor 23, and osteoprotegerin). <b><i>Methods:<\/i><\/b> A cross-sectional study included 17 dialysis patients, and results from <sup>18<\/sup>F-NaF PET\/CT scans and the biomarkers were directly compared with the results of histomorphometric analyses of tetracycline double-labeled trans-iliac bone biopsies. <b><i>Results:<\/i><\/b> Bone biopsies showed 40% high, 20% normal, and 40% low bone turnover. No biopsies had generalized abnormal mineralization, and the bone volume\/total tissue volume was low in 80% and high in 7%. The pelvic skeletal plasma clearance (K<sub>i<\/sub>) from <sup>18<\/sup>F-NaF PET\/CT correlated with bone turnover parameters obtained by bone biopsy (activation frequency: <i>r<\/i> = 0.82, <i>p<\/i> &#x3c; 0.01; bone formation rate\/bone surface: <i>r<\/i> = 0.81, <i>p<\/i> &#x3c; 0.01), and K<sub>i<\/sub> defined low turnover with high sensitivity (83%) and specificity (100%). CT-derived radiodensity correlated with bone volume, <i>r<\/i> = 0.82, <i>p<\/i> &#x3c; 0.01. Of the biomarkers, only osteocalcin showed a correlation with turnover assessed by histomorphometry. <b><i>Conclusion:<\/i><\/b> In conclusion, <sup>18<\/sup>F-NaF PET\/CT may be applicable for noninvasive assessment of bone turnover and volume in CKD-MBD. <\/jats:p>","DOI":"10.1159\/000524961","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T21:00:32Z","timestamp":1654635632000},"page":"490-502","source":"Crossref","is-referenced-by-count":16,"title":["Bone Turnover, Mineralization, and Volume Estimated by <sup>18<\/sup>F-Sodium Fluoride PET\/CT and Biomarkers in Chronic Kidney Disease: Mineral and Bone Disorder Compared with Bone Biopsy"],"prefix":"10.1159","volume":"53","author":[{"given":"Marie Houmaa","family":"Vrist","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-6852","authenticated-orcid":false,"given":"Ann Mai H.","family":"\u00d8stergaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4525-7283","authenticated-orcid":false,"given":"Stine S.","family":"Langaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank H.","family":"Mose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-5491","authenticated-orcid":false,"given":"Claire A.","family":"Fynbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rn","family":"Theil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente L.","family":"Langdahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Lauridsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper N.","family":"Bech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126\/science.95.2467.388"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2017.04.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/BF02058664"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5414\/cnp65235"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.309"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/524961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:58:41Z","timestamp":1745420321000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000524961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":5,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,7,12]]},"published-print":{"date-parts":[[2022,7,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000524961","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.20015120","asserted-by":"subject"}]},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}