{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:37:35Z","timestamp":1793191055754,"version":"4.5.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"9","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> Robust clinical evidence on the efficacy and safety of endoscopic lung volume reduction (ELVR) with one-way valves in patients with severe lung emphysema with chronic hypercapnic respiratory failure is lacking. <b><i>Objective:<\/i><\/b> The aim of this study was to compare patient characteristics, clinical outcome measures, and incidences of adverse events between patients with severe COPD undergoing ELVR with one-way valves and with either a partial pressure of carbon dioxide (pCO<sub>2<\/sub>) of \u226445 mm Hg or with pCO<sub>2<\/sub> &#x3e;45 mm Hg. <b><i>Methods:<\/i><\/b> This was a multicentre prospective study of patients with severe lung disease who were evaluated based on lung function, exercise capacity (6-min walk test [6-MWT]), and quality-of-life tests. <b><i>Results:<\/i><\/b> Patients with pCO<sub>2<\/sub> \u226445 mm Hg (<i>n<\/i> = 157) and pCO<sub>2<\/sub> &#x3e;45 mm Hg (<i>n<\/i> = 40) showed similar baseline characteristics. Patients with pCO<sub>2<\/sub> \u226445 mm Hg demonstrated a significant increase in forced expiratory volume in 1 s (<i>p<\/i> &#x3c; 0.001), a significant decrease in residual volume (RV) (<i>p<\/i> &#x3c; 0.001), and significant improvements in the quality of life and 6-MWT at the 3-month follow-up. Patients with pCO<sub>2<\/sub> &#x3e;45 mm Hg had significant improvements in RV only (<i>p<\/i> &#x3c; 0.05). There was a significant decrease in pCO<sub>2<\/sub> between baseline and follow-up in hypercapnic patients, relative to the decrease in patients with pCO<sub>2<\/sub> \u226445 mm Hg (<i>p<\/i> = 0.008). Patients who were more hypercapnic at baseline showed a greater reduction in pCO<sub>2<\/sub> after valve placement (<i>r<\/i> = \u22120.38, <i>p<\/i> &#x3c; 0.001). Pneumothorax was the most common adverse event in both groups. <b><i>Conclusions:<\/i><\/b> ELVR with one-way valves seems clinically beneficial with a remarkably good safety profile for patients with chronic hypercapnic respiratory failure. <\/jats:p>","DOI":"10.1159\/000524996","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T21:00:38Z","timestamp":1656968438000},"page":"823-832","source":"Crossref","is-referenced-by-count":17,"title":["Endoscopic Lung Volume Reduction with One-Way Valves in Patients with Severe Chronic Obstructive Pulmonary Disease with Hypercapnia"],"prefix":"10.1159","volume":"101","author":[{"given":"Pavlina","family":"Lenga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Grah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Ruwwe-Gl\u00f6senkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Saccomanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"R\u00fcckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Eggeling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Gl\u00e4ser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-8440","authenticated-orcid":false,"given":"Sylke","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0387-0760","authenticated-orcid":false,"given":"Stephan","family":"Eisenmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3274-777X","authenticated-orcid":false,"given":"Paul","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Andreas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hinterthaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6779-1826","authenticated-orcid":false,"given":"Joachim","family":"Pfannschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Gebhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-5762","authenticated-orcid":false,"given":"Franz","family":"Stanzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lique","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kirschbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Becke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf-Harto","family":"H\u00fcbner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on 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