{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:10Z","timestamp":1790620990798,"version":"4.1.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> The aims of the study were to describe the neurodevelopmental outcome of extremely low birth weight (ELBW) infants with parenteral nutrition-associated cholestasis (PNAC) and to assess whether PNAC is associated with adverse neurodevelopmental outcome. <b><i>Methods:<\/i><\/b> The study is a secondary analysis of controlled trial (June 2012\u2013October 2017) on PNAC incidence in ELBW infants receiving two different parenteral lipid emulsions (mixed lipid emulsion containing fish oil vs. soybean oil-based). Neurodevelopmental follow-up at 12- and 24-month corrected age was compared in infants with and without PNAC. A machine learning-based regression analysis was used to assess whether PNAC was associated with adverse neurodevelopmental outcome. <b><i>Results:<\/i><\/b> For assessment of neurodevelopmental outcome (Bayley-III), 174 infants were available at 12-month (PNAC: <i>n<\/i> = 21; no PNAC: <i>n<\/i> = 153) and 164 infants at 24-month (PNAC: <i>n<\/i> = 20; no PNAC: <i>n<\/i> = 144) corrected age. The neurodevelopment of ELBW infants with PNAC was globally delayed, with significantly lower cognitive, language, and motor scores at both 12- and 24-month corrected age. Regression analyses revealed that PNAC was associated with an adverse motor outcome. <b><i>Conclusion:<\/i><\/b> ELBW infants with PNAC are at increased risk for adverse neurodevelopmental outcome. <\/jats:p>","DOI":"10.1159\/000525003","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T21:00:43Z","timestamp":1654808443000},"page":"501-509","source":"Crossref","is-referenced-by-count":11,"title":["Neurodevelopmental Outcome of Extremely Low Birth Weight Infants with Cholestasis at 12 and 24 Months"],"prefix":"10.1159","volume":"119","author":[{"given":"Margarita","family":"Thanhaeuser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3215-8115","authenticated-orcid":false,"given":"David","family":"Steyrl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6278-8866","authenticated-orcid":false,"given":"Renate","family":"Fuiko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Brandstaetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Thajer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9634-8914","authenticated-orcid":false,"given":"Mercedes","family":"Huber-Dangl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4806-0312","authenticated-orcid":false,"given":"Nadja","family":"Haiden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-5497","authenticated-orcid":false,"given":"Angelika","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Repa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.06.944"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2483"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013171.pub2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1571202"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002380"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-59"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.2175"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.12.014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318259ed20"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29599"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008342.pub2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(83)80087-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101086"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/525003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/525003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:59:10Z","timestamp":1745420350000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000525003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,7,18]]},"published-print":{"date-parts":[[2022,7,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000525003","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.20036720","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}