{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:32:41Z","timestamp":1747193561720,"version":"3.40.5"},"reference-count":17,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> This study investigated whether a novel therapy called ischemic conditioning (IC) improves walking capacity and lower extremity muscle performance in patients with peripheral vascular disease who experience intermittent claudication. <b><i>Methods:<\/i><\/b> Forty-three patients with claudication were enrolled and received either IC or IC Sham for 2 weeks in this randomized, controlled, double-blinded, prospective study. IC sessions involved five cycles of alternating 5-min inflations of a blood pressure cuff to 225 mm Hg (25 mm Hg for IC Sham) and 5-min deflations, around the thigh of the affected lower extremity. <b><i>Results:<\/i><\/b> There was no difference in the change in claudication onset time (\u0394 = 114 \u00b1 212 s IC vs. 104 \u00b1 173 s IC Sham; <i>p<\/i> = 0.67) or peak walking time (\u0394 = 42 \u00b1 139 s IC vs. 12 \u00b1 148 s IC Sham; <i>p<\/i> = 0.35) between the IC and IC Sham groups. At the level of the knee, participants in the IC group performed more work (\u0394 = 3,029 \u00b1 4,999 J IC vs. 345 \u00b1 2,863 J IC Sham; <i>p<\/i> = 0.03) and displayed a greater time to muscle fatigue (\u0394 = 147 \u00b1 221 s IC vs. \u221227 \u00b1 236 s IC Sham; <i>p<\/i> = 0.01). <b><i>Discussion\/Conclusion:<\/i><\/b> In patients with claudication, IC improved total work performed and time to fatigue at the knee but did not change walking parameters. <\/jats:p>","DOI":"10.1159\/000525166","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T21:00:32Z","timestamp":1662498032000},"page":"314-323","source":"Crossref","is-referenced-by-count":1,"title":["A Pilot Study Examining the Effects of Ischemic Conditioning on Walking Capacity and Lower Extremity Muscle Performance in Patients with Claudication"],"prefix":"10.1159","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-3843","authenticated-orcid":false,"given":"Rory J.","family":"Loo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max V.","family":"Wohlauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey S.","family":"Tarima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Weseman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer N.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7186-2850","authenticated-orcid":false,"given":"Neel A.","family":"Mansukhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Durand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.12.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1177\/000331970105200102"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2012.04.024"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000990.pub3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.05.111"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-013-0231-z"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.74.5.1124"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318262cb17"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.23736\/S0022-4707.18.08400-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2018.07.046"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9592378"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1123\/ijspp.2015-0204"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X9600100111"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.10.031"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-015-6621-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12304"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.42"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/525166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/525166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:01:40Z","timestamp":1745420500000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000525166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,10,20]]},"published-print":{"date-parts":[[2022,10,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000525166","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.20964304","asserted-by":"subject"}]},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"type":"print","value":"1018-1172"},{"type":"electronic","value":"1423-0135"}],"subject":[],"published":{"date-parts":[[2022]]}}}