{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:48:50Z","timestamp":1765295330395,"version":"3.40.4"},"reference-count":31,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The effect of supplemental oxygen on sleep has not been studied in preterm infants. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We studied 18 stable late-preterm infants with observed periodic breathing at a median gestational age of 36 weeks. Polysomnography was performed on room air and on 25% oxygen-enriched ambient air. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Supplemental oxygen did not affect sleep stage distribution, sleep efficiency, the frequency of sleep stage transitions, the appearance of rapid-eye movement (REM) sleep periods, or the high number of spontaneous arousals. The percentage in periodic breathing out of total sleep time decreased from 10% (interquartile range [IQR] 5\u20139%) on room air to 1% (IQR 0\u20133%) (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) on supplemental oxygen. Also, the number of central apneas decreased from 48 (IQR 32\u201368) to 23 (IRQ 15\u201332) per hour (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001), and the number of oxygen desaturations of a minimum 3% from 38 (IQR 29\u201374) to 10 (IQR 5\u201324) per hour (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001). On room air in non-REM sleep, the median end-tidal carbon dioxide values were systematically lower during periodic breathing at 5.1 (IQR 4.6\u20136.4) kPa than during stable breathing at 5.5 (4.9\u20135.9) kPa (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In late-preterm infants, supplemental oxygen effectively reduces periodic breathing and the number of oxygen desaturations while having no significant effect on sleep. The results support the importance of carotid body over-reactivity on the genesis of periodic breathing in preterm infants. <\/jats:p>","DOI":"10.1159\/000525196","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T21:01:23Z","timestamp":1662757283000},"page":"567-574","source":"Crossref","is-referenced-by-count":6,"title":["Supplemental Oxygen Treats Periodic Breathing without Effects on Sleep in Late-Preterm Infants"],"prefix":"10.1159","volume":"119","author":[{"given":"Maija","family":"Sepp\u00e4-Moilanen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sture","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turkka","family":"Kirjavainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2019.101072"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.5725"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.03.021"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.05.065"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.050"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2013.05.026"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14541"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1981.tb01957.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.05.007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1942.02010060064002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.6.1.55"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.14.2.104"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.50.2.202"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197304000-00020"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.1.116"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000140.pub2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.5.884"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2006.06.009"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2002.0243"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5600"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(95)92966-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1099-0496(199810)26:4%3c235::aid-ppul1%3e3.0.co;2-3"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2012.06.003"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/16.suppl_8.s37"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c110057"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18440-1_19"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2019.05.008"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.01.046"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2019.05.006"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0227"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054065"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/525196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/525196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:01:58Z","timestamp":1745420518000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000525196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,10,3]]},"published-print":{"date-parts":[[2022,10,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000525196","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.21069775","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2022]]}}}