{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:33:31Z","timestamp":1792020811136,"version":"4.4.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> The aim of this study is to evaluate signal alteration in the inner ear using three-dimensional (3D)-constructive interference in steady state (CISS) sequence in patients with M\u00e9ni\u00e8re\u2019s disease and labyrinthitis and its correlation with clinical and audiological parameters. <b><i>Methods:<\/i><\/b> The medical records of the department of otorhinolaryngology were searched for patients with M\u00e9ni\u00e8re\u2019s disease or labyrinthitis who underwent MRI with 3D-CISS sequence. Blinded analysis of these patients and of MRI from control subjects without middle or inner ear symptoms was performed to detect any signal asymmetry of the inner ear structures. The results were correlated with clinical symptoms and results of audiological and vestibular tests. <b><i>Results:<\/i><\/b> Fifty-eight patients with definite M\u00e9ni\u00e8re\u2019s disease and 5 patients with labyrinthitis as well as 41 control exams were included. A separate analysis was performed for patients with probable M\u00e9ni\u00e8re\u2019s disease (<i>n<\/i> = 68). A total of 172 3D-CISS sequences were analyzed by 2 blinded independent neuroradiologists. A CISS-hypointense signal of the inner ear structures was found in 3 patients with definite M\u00e9ni\u00e8re\u2019s disease (5.2%), in 4 patients with probable M\u00e9ni\u00e8re\u2019s disease (5.9%), and 2 patients with labyrinthitis (40%). No CISS hypointensity was found in the control group. Although no significant difference in symptoms or audiological test results was found between patients with and without this signal change, the side of hypointensity was frequently correlated with the symptomatic side and with hearing impairment. <b><i>Discussion\/Conclusion:<\/i><\/b> CISS hypointensity of the inner ear structures was evident in patients with clinical conditions other than vestibular schwannoma \u2013 more frequently in labyrinthitis than in M\u00e9ni\u00e8re\u2019s disease. This signal alteration was frequently encountered on the same symptomatic side as that of the pathological audiology tests, but it is not a predictor for hearing or vestibular impairment. <\/jats:p>","DOI":"10.1159\/000525419","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T21:00:29Z","timestamp":1661806829000},"page":"449-457","source":"Crossref","is-referenced-by-count":1,"title":["Signal Alteration of the Inner Ear on High-Resolution Three-Dimensional Constructive Interference in Steady State Sequence in Patients with M\u00e9ni\u00e8re\u2019s Disease and Labyrinthitis"],"prefix":"10.1159","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-1069","authenticated-orcid":false,"given":"Arsany","family":"Hakim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-4215","authenticated-orcid":false,"given":"Sara-Lynn","family":"Hool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Yassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-0332","authenticated-orcid":false,"given":"Philipe Sebastian","family":"Breiding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2603-8915","authenticated-orcid":false,"given":"Manuela","family":"Pastore-Wapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Caversaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6927-0664","authenticated-orcid":false,"given":"Lukas","family":"Anschuetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7502-4814","authenticated-orcid":false,"given":"Franca","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.03.036"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020201767"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-019-02258-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3936"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021656"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00978"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3233\/VES-190649"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218292"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/77\/7\/076601"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.03.044"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1966.00760030397003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/000348947108000105"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-018-1361-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2017.09.011"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/525419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/525419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:04:46Z","timestamp":1745420686000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000525419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":14,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,11,24]]},"published-print":{"date-parts":[[2022,11,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000525419","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.20709214","asserted-by":"subject"}]},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"value":"1420-3030","type":"print"},{"value":"1421-9700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}