{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:33:05Z","timestamp":1747193585499,"version":"3.40.5"},"reference-count":18,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomed Hub"],"abstract":"<b><i>Introduction:<\/i><\/b> This study aimed to describe the quantitative features of the microvasculature in the cystic lesions of branch retinal vein occlusion (BRVO). <b><i>Methods:<\/i><\/b> A total of 43 eyes with BRVO, treated with anti-vascular endothelial growth factor therapy, were analyzed. Using wide-field swept-source optical coherence tomography angiography (OCTA), en face OCT images were obtained by depth-integrated reflectivity of the retina, and vascular density (VD), vascular length (VL), vascular lacunarity, and fractal dimension (FD) were evaluated in a 12 \u00d7 12-mm area of retinal nonperfusion. <b><i>Results:<\/i><\/b> The mean area of affected lesions was 38.7 \u00b1 19.8 mm<sup>2<\/sup>, and cystic lesions were 8.5 \u00b1 10.1 mm<sup>2<\/sup>. VD, VL, and FD were significantly decreased in the cystic lesions compared to other affected lesions in the same eyes (<i>p<\/i> = 0.0010, <i>p<\/i> = 0.0001, and <i>p<\/i> = 0.0003, respectively) and in all eyes (<i>p<\/i> = 0.0281, <i>p<\/i> = 0.0050, and <i>p<\/i> &#x3c; 0.0001, respectively). VD in cystic lesions within the vascular arcade (25 eyes) correlated with best-corrected visual acuity on OCTA (<i>r<\/i> = \u22120.433, and <i>p<\/i> = 0.0492). <b><i>Conclusions:<\/i><\/b> Vascular structure in the cystic lesions was unpreserved compared to the other lesions in BRVO. These findings may help in understanding the pathophysiology of retinal edema in BRVO. <\/jats:p>","DOI":"10.1159\/000525497","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T21:03:53Z","timestamp":1660683833000},"page":"99-105","source":"Crossref","is-referenced-by-count":1,"title":["Microvascular Changes in the Cystic Lesion of Branch Retinal Vein Occlusion Imaged by Swept-Source Optical Coherence Tomography Angiography"],"prefix":"10.1159","volume":"7","author":[{"given":"Satoko","family":"Araki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Sakimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Shiozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9320-5408","authenticated-orcid":false,"given":"Chikako","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Sayanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0631-9242","authenticated-orcid":false,"given":"Hirokazu","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohji","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.01.058"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.02.021"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.032"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14087"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46514-z"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.0668"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1500185112"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.03.033"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15673"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S37185"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.05.039"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21447"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027385"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.10"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312769"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-311942"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/42.870662"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000862"}],"container-title":["Biomedicine Hub"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/525497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/525497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:05:41Z","timestamp":1745420741000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000525497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,9,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000525497","archive":["Portico"],"relation":{},"ISSN":["2296-6870"],"issn-type":[{"type":"electronic","value":"2296-6870"}],"subject":[],"published":{"date-parts":[[2022,8,16]]}}}